| Autor: |
Alexander A. Smoligovets, Jay T. Groves, Nicole C. Fay, Hung-Jen Wu, Yan Yu |
| Jazyk: |
angličtina |
| Předmět: |
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| Zdroj: |
Biophysical Journal. (3):377a |
| ISSN: |
0006-3495 |
| DOI: |
10.1016/j.bpj.2011.11.2057 |
| Popis: |
Activation of T cell receptor (TCR) by antigens occurs in concert with an elaborate multi-scale spatial reorganization of proteins at the immunological synapse, the junction between a T cell and an antigen-presenting cell (APC). Signaling through discrete T cell receptors (TCRs) in the context of immunological synapse, involves the orchestrated movement and reorganization of TCR microclusters. The frictional coupling between the actin cytoskeleton and protein microclusters has been proposed to be essential for the spatial organization of signaling receptors at all length scales, but the role of molecular motors in this process is largely unknown. By using the hybrid live T cells-supported membrane platform, we study the role of myosin motors in the synapse formation of primary T cells and explore a possible mechanical mechanism of signal modulation involving myosin II. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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