Translesion DNA Synthesis and Carcinogenesis

Autor:	M P Smal, Elizaveta O. Boldinova, R I Goncharova, Alena V. Makarova, A. D. Stolyarenko, Rafil Khairullin, R N Chuprov-Netochin, Evgeniy S. Shilkin
Rok vydání:	2020
Předmět:	DNA Replication DNA Repair DNA polymerase DNA repair DNA damage Biophysics DNA-Directed DNA Polymerase Biochemistry Biochemistry Genetics and Molecular Biology (miscellaneous) 03 medical and health sciences chemistry.chemical_compound Neoplasms Animals Humans Polymerase 0303 health sciences biology DNA synthesis Chemistry 030302 biochemistry & molecular biology DNA replication General Medicine Molecular biology genomic DNA DNA Polymerase iota biology.protein Geriatrics and Gerontology DNA DNA Damage
Zdroj:	Biochemistry (Moscow). 85:425-435
ISSN:	1608-3040 0006-2979
DOI:	10.1134/s0006297920040033
Popis:	Tens of thousands of DNA lesions are formed in mammalian cells each day. DNA translesion synthesis is the main mechanism of cell defense against unrepaired DNA lesions. DNA polymerases iota (Pol ι), eta (Pol η), kappa (Pol κ), and zeta (Pol ζ) have active sites that are less stringent toward the DNA template structure and efficiently incorporate nucleotides opposite DNA lesions. However, these polymerases display low accuracy of DNA synthesis and can introduce mutations in genomic DNA. Impaired functioning of these enzymes can lead to an increased risk of cancer.
Databáze:	OpenAIRE
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