Mandibular Ewing Sarcoma With Chromosomal Translocation t(21;22)(q22;q12)
| Autor: | Maiko Shibasaki, Toshinori Iwai, Yoshiaki Inayama, Yoshiro Matsui, Jiro Maegawa, Iwai Tohnai, Shinsuke Ohta, Kenji Mitsudo, Shumpei Yokota, Tomoko Yokosuka |
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| Rok vydání: | 2013 |
| Předmět: |
Male
Oncogene Proteins Fusion Chromosomes Human Pair 21 Chromosomes Human Pair 22 Population Chromosomal translocation Sarcoma Ewing Translocation Genetic medicine Humans Child education education.field_of_study business.industry Chromosome General Medicine medicine.disease Combined Modality Therapy Mandibular Neoplasms Primary bone Otorhinolaryngology Cancer research Osteosarcoma Surgery Sarcoma Chromosome 21 business Chromosome 22 Transcription Factors |
| Zdroj: | Journal of Craniofacial Surgery. 24:1469-1472 |
| ISSN: | 1049-2275 |
| DOI: | 10.1097/scs.0b013e31829030ed |
| Popis: | Ewing sarcoma (ES) is a primary bone malignant neoplasm and is the second most common primary malignancy of the bone found in childhood and adolescence after osteosarcoma. ES has an annual frequency in the population younger than 20 years of approximately 2.9 per million. ES occurs most frequently in the long bones of the extremities and pelvis and very rarely in the jaw. Recently, it was revealed that chromosomal translocation t(11;22)(q24;q12), which fuses the EWS gene on chromosome 22 and the FLI-1 gene on chromosome 11, occurs in most cases of ES. We report here a rare case of mandibular ES in a 10-year-old child with chromosomal translocation t(21;22)(q22;q12) in which the EWS gene is fused with the ERG gene on chromosome 21. |
| Databáze: | OpenAIRE |
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