Molecular basis for the nonexpression of V beta 17 in some strains of mice

Autor:	Wade T, Bill J, Philippa Marrack, Palmer E, Jw, Kappler
Rok vydání:	1988
Předmět:	Mice Base Sequence T-Lymphocytes Molecular Sequence Data Immunology Receptors Antigen T-Cell Animals Antibodies Monoclonal Immunology and Allergy Mice Inbred Strains Amino Acid Sequence RNA Messenger Gene Rearrangement beta-Chain T-Cell Antigen Receptor
Zdroj:	Europe PubMed Central
ISSN:	1550-6606 0022-1767
DOI:	10.4049/jimmunol.141.6.2165
Popis:	The TCR alpha/beta variable element V beta 17a is expressed in all strains of mice carrying the V beta a complex in which about half of the V beta elements have been lost due to a large deletion. The mAb KJ23a detects V beta 17a containing alpha/beta receptors in these mice. Mouse strains with the V beta b complex carry a full complement of V beta genes including a structural gene for V beta 17 (V beta 17b), but no T cells reactive with KJ23a are present in these mice. Among random peripheral T cell hybridomas prepared from V beta b mice, occasional V beta 17b transcripts are found. The sequence of one of these transcripts reveals a single base difference from V beta 17a which results in a termination codon within the coding region inactivating the gene.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::31f49bc9d4e84a826145c18da969ceeb https://doi.org/10.4049/jimmunol.141.6.2165 Zobrazit plný text záznamu