Statine based tripeptides as potent inhibitors of HIV-1 replication
| Autor: | D. Nisato, Jean-Claude Chermann, E. Bignon, J.A. Fehrentz, S. Venaud, B. Chomier |
|---|---|
| Rok vydání: | 1992 |
| Předmět: |
medicine.medical_treatment
Molecular Sequence Data Biophysics Tripeptide Virus Replication Biochemistry Cell Line Structure-Activity Relationship chemistry.chemical_compound HIV Protease Statine Consensus sequence medicine Humans Potency Amino Acid Sequence Amino Acids Molecular Biology chemistry.chemical_classification Protease biology HIV Protease Inhibitors Cell Biology In vitro Kinetics Enzyme chemistry Enzyme inhibitor HIV-1 biology.protein Oligopeptides |
| Zdroj: | Biochemical and Biophysical Research Communications. 188:873-878 |
| ISSN: | 0006-291X |
| DOI: | 10.1016/0006-291x(92)91137-f |
| Popis: | Starting from highly potent HIV-1 protease pepstatine analog inhibitors, we have tried to find the minimum consensus sequence which is necessary to conserve anti-protease potency and antiviral activity. We describe here some statine based tripeptides which exhibit high affinity for the protease and are able to inhibit the reproductive cycle of HIV-1 in MT-4-infected cells. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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