Sensing danger: toll-like receptors and outcome in allogeneic hematopoietic stem cell transplantation
| Autor: | K Müller, B Kornblit |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
medicine.medical_treatment Hematopoietic stem cell transplantation 03 medical and health sciences 0302 clinical medicine Immune system Transplantation Immunology medicine Animals Humans Transplantation Homologous Progenitor cell Receptor Transplantation business.industry Toll-Like Receptors Pattern recognition receptor Hematopoietic Stem Cell Transplantation Hematology medicine.disease surgical procedures operative 030104 developmental biology Graft-versus-host disease Treatment Outcome Receptors Pattern Recognition Immunology Stem cell business 030215 immunology |
| Zdroj: | Bone marrow transplantation. 52(4) |
| ISSN: | 1476-5365 |
| Popis: | Pattern recognition receptors (PRRs) such as Toll-like receptors (TLRs) play key roles in initiating innate and adaptive immune responses. Based mainly on animal studies there is growing evidence to suggest that TLRs are involved in the development of chemotherapy-induced mucositis and in the propagation of graft versus host reactions as well as graft versus tumor effects in allogeneic hematopoietic stem cell transplantation (HSCT). In this review we discuss these findings along with the emerging, although still preliminary, clinical evidence, that points to a role of PRRs in determining the outcome of HSCT and new therapeutic perspectives that may be related to this development. |
| Databáze: | OpenAIRE |
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