Modulation of Placental Gene Expression in Small-for-Gestational-Age Infants
| Autor: | Adam D. Ewing, Peter J. Prentis, Jessica L. O’Callaghan, Vicki L. Clifton, Yvette D. Miller, Elise S. Pelzer |
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| Rok vydání: | 2020 |
| Předmět: |
Male
0301 basic medicine sga placenta lcsh:QH426-470 Gene Expression Gestational Age Review Biology Bioinformatics Fetal Development Transcriptome 03 medical and health sciences 0302 clinical medicine Pregnancy Placenta Genetics medicine Humans Genetics (clinical) Regulation of gene expression Fetus Fetal Growth Retardation 030219 obstetrics & reproductive medicine Microbiota Infant Newborn Gene Expression Regulation Developmental Epigenome DNA Methylation medicine.disease Placentation lcsh:Genetics Low birth weight 030104 developmental biology medicine.anatomical_structure bacterial signatures Infant Small for Gestational Age DNA methylation Small for gestational age Female medicine.symptom gene regulation |
| Zdroj: | Genes, Vol 11, Iss 1, p 80 (2020) Genes |
| ISSN: | 2073-4425 |
| DOI: | 10.3390/genes11010080 |
| Popis: | Small-for-gestational-age (SGA) infants are fetuses that have not reached their genetically programmed growth potential. Low birth weight predisposes these infants to an increased risk of developing cardiovascular, metabolic and neurodevelopmental conditions in later life. However, our understanding of how this pathology occurs is currently incomplete. Previous research has focused on understanding the transcriptome, epigenome and bacterial signatures separately. However, we hypothesise that interactions between moderators of gene expression are critical to understanding fetal growth restriction. Through a review of the current literature, we identify that there is evidence of modulated expression/methylation of the placental genome and the presence of bacterial DNA in the placental tissue of SGA infants. We also identify that despite limited evidence of the interactions between the above results, there are promising suggestions of a relationship between bacterial signatures and placental function. This review aims to summarise the current literature concerning fetal growth from multiple avenues and propose a novel relationship between the placental transcriptome, methylome and bacterial signature that, if characterised, may be able to improve our current understanding of the placental response to stress and the aetiology of growth restriction. |
| Databáze: | OpenAIRE |
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