Variations on the theme: allosteric control in hemoglobin
| Autor: | Maurizio Brunori |
|---|---|
| Přispěvatelé: | Department of Biochemical Sciences 'Rossi Fanelli', Institut Pasteur, Fondation Cenci Bolognetti - Istituto Pasteur Italia, Fondazione Cenci Bolognetti, Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP)-Università degli Studi di Roma 'La Sapienza' = Sapienza University [Rome] |
| Rok vydání: | 2013 |
| Předmět: |
Models
Molecular Stereochemistry 030303 biophysics Allosteric regulation MESH: Protein Structure Secondary Heme Biology MESH: Allosteric Regulation Biochemistry Protein Structure Secondary Hemoglobins 03 medical and health sciences Allosteric Regulation MESH: Protein Stability Animals Humans MESH: Protein Binding MESH: Animals [SDV.BBM]Life Sciences [q-bio]/Biochemistry Molecular Biology MESH: Allosteric Site Molecular Biology 030304 developmental biology Cognitive science 0303 health sciences MESH: Humans MESH: Kinetics Protein Stability Cell Biology Structure and function Oxygen Kinetics MESH: Hemoglobins Mechanism (philosophy) MESH: Heme Allosteric Site MESH: Oxygen MESH: Models Molecular Protein Binding Theme (narrative) |
| Zdroj: | FEBS Journal FEBS Journal, Wiley, 2014, 281 (2), pp.633-43. ⟨10.1111/febs.12586⟩ |
| ISSN: | 1742-464X 1742-4658 |
| DOI: | 10.1111/febs.12586 |
| Popis: | International audience; Conformational selection between pre-existing structural states of an oligomeric protein was the conceptual step behind the formulation of Monod-Wyman-Changeux (MWC) allosteric theory. Variations on the basic theme of allosteric control are briefly illustrated in this paper by reference to some hemoglobins from different species whose functional properties were found to respond to specific physiological requirements. In my opinion the enormous success of the allosteric theory may be attributed not only to its efficiency in accounting for data and its formal mathematical elegance, but also because the selective mechanism conforms to the founding concept of Darwinian evolution. |
| Databáze: | OpenAIRE |
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