Home-based HPV self-sampling assisted by a cloud-based electronic data system: Lessons learnt from a pilot community cervical cancer screening campaign in rural Ethiopia

Autor: Dietmar Schmidt, Tamrat Abebe, Abebaw Gebeyehu, Till Bärnighausen, Kassahun Alemu, Hermann Bussmann, Felix Jede, Heike Sartor, Gashaw Andargie, Aleksandra Pesic, Timoté Vaucher, Bewketu Abebe, Theresa Brandt, Binyam Tilahun, Brhanu Teka, Andreas M. Kaufmann, Solomon Berhe Wubneh, Magnus von Knebel Doeberitz, Molla Gedefaw, Temesgen Azemeraw, Michael Byczkowski, Zelalem Ayichew
Jazyk: angličtina
Rok vydání: 2020
Předmět:
Rural Population
population
Uterine Cervical Neoplasms
Cloud computing
Pilot Projects
Community
Cervical cancer screening
human-papillomavirus
Electronic data system
Home-based
0302 clinical medicine
prevention
collection
Rural
030212 general & internal medicine
Early Detection of Cancer
Colposcopy
medicine.diagnostic_test
smear
Self-sampling
Middle Aged
health workers
Infectious Diseases
030220 oncology & carcinogenesis
Electronic data
Female
visual inspection
HPV testing
Adult
medicine.medical_specialty
Referral
Health Promotion
Article
lcsh:Infectious and parasitic diseases
Specimen Handling
03 medical and health sciences
Virology
medicine
eHealth
Humans
lcsh:RC109-216
Aged
Electronic Data Processing
business.industry
acetic-acid
Papillomavirus Infections
Cloud Computing
Uterine Cervical Dysplasia
Triage
Rural ethiopia
p16/ki-67 dual stain cytology
Self-Testing
Family medicine
positive women
program
Ethiopia
business
Zdroj: Papillomavirus Research
Papillomavirus Research, Vol 9, Iss, Pp-(2020)
ISSN: 2405-8521
Popis: Primary HPV testing and triage of HPV-positive women is an effective cervical cancer screening strategy. Such a multi-visit screening algorithm is also promising for community-based screening in resource-poor communities, provided a robust tracking system is in place. A cervical cancer screening campaign was conducted in a rural community in Ethiopia. All women aged 25-65 years were offered genital self-sampling using the Evalyn Brush (R). Samples were HPV-DNA-tested at a central laboratory. Key indicators were captured on tablet computers and linked by a cloud-based information system. HPV-positive women were examined at the local clinic using portable colposcopy, p16/Ki-67 dual stain cytology and biopsy examination. CIN2+ women were referred for LEEP to the referral hospital. Of 749 enumerated age-eligible women 634 (85%, (95% CI 82-88)) consented to screening, 429 samples were adequate for HPV testing, giving a total testing coverage of 57% (95% CI 53-62). The hrHPV prevalence was 14% (95% CI 5-22), 72% (95% CI 60-84) attended the clinic for a triage examination. Home-based HPV-DNA self-sampling and clinic-based triage assisted by cloud-based information technology is feasible in rural Ethiopia. Key components of such strategy are broad community awareness, high competency of community workers, and establishment of an adequate self-sampling and HPV-DNA testing platform.
Databáze: OpenAIRE
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