Adenoviral activin A expression prevents vein graft intimal hyperplasia in a rat model
| Autor: | Gert Grauls, Cathrien A. Bruggeman, Frank R. M. Stassen, Geoffrey T.L. Kloppenburg |
|---|---|
| Rok vydání: | 2008 |
| Předmět: |
Male
Pulmonary and Respiratory Medicine Neointima medicine.medical_specialty Intimal hyperplasia Genetic Vectors Lumen (anatomy) Constriction Pathologic Femoral artery Muscle Smooth Vascular Adenoviridae Veins Internal medicine medicine.artery medicine Animals Humans Abdominal Muscles Cell Proliferation Inhibin-beta Subunits Hyperplasia business.industry Graft Occlusion Vascular Genetic Therapy medicine.disease Actins Activins Rats Femoral Artery Stenosis medicine.anatomical_structure Endocrinology Bromodeoxyuridine Rats Inbred Lew Models Animal Surgery medicine.symptom Tunica Intima Cardiology and Cardiovascular Medicine business Vascular Surgical Procedures Artery Muscle contraction |
| Zdroj: | Interactive CardioVascular and Thoracic Surgery. 8:31-34 |
| ISSN: | 1569-9293 |
| DOI: | 10.1510/icvts.2008.182329 |
| Popis: | Autologus vein grafts are used for coronary artery and infra-inguinal bypass procedures. Although initially successful, long-term patency rates are limited by lumen occlusion due to neointima formation by smooth muscle cell hyperplasia. Gene therapy to prevent this smooth muscle cell proliferation has been studied extensively with limited success. Activin A, a member of the transforming growth factor-beta super family, promotes the contractile phenotype of smooth muscle cells. Maintaining the contractile phenotype could be a novel strategy to prevent intimal hyperplasia. In an epigastric vein-to-common femoral artery interposition grafts rat model, activin A over-expression resulted in a significant decrease in intimal cross-sectional area and percentage stenosis as compared to the control group. BrdU staining identified lower proliferation rates of the smooth muscle cells in the group treated with activin A. We report for the first time evidence that activin A can diminish vein graft failure in a rat model supporting a novel strategy to prevent intimal hyperplasia. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|