No association of IL-12p40 pro1.1 polymorphism with juvenile idiopathic arthritis
| Autor: | Tobias Schwarz, Dirk Foell, Johannes-Peter Haas, Norbert Wagner, Guenther E. Dannecker, Angela Rösen-Wolff, Klaus Tenbrock, Jan Müller-Berghaus, Thomas Eggermann, Carsten Schepp, Gerd Ganser, Nora Honke, Kim Ohl, Hermann J. Girschick, Christiane Eberhardt, Henner Morbach |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: |
medicine.medical_specialty
Arthritis Polymerase Chain Reaction Pathogenesis Rheumatology Internal medicine Genotype medicine IL-12B promoter polymorphism Immunology and Allergy Juvenile Humans Pediatrics Perinatology and Child Health Promoter Regions Genetic IL-12p40 ddc:618 Oligoarthritis Polymorphism Genetic business.industry Interleukin-12 Subunit p40 Case-control study Juvenile idiopathic arthritis medicine.disease Arthritis Juvenile Case-Control Studies Pediatrics Perinatology and Child Health Immunology Polyarthritis business Research Article |
| Zdroj: | Pediatric Rheumatology Online Journal Pediatric rheumatology 13(1), 61 (2015). doi:10.1186/s12969-015-0059-z |
| ISSN: | 1546-0096 |
| Popis: | Background: IL-12p40 plays an important role in the activation of the T-cell lines like Th17 and Th1-cells. Theses cells are crucial in the pathogenesis of juvenile idiopathic arthritis. A polymorphism in its promoter region and the genotype IL12p40 pro1.1 leads to a higher production of IL-12p40. We studied whether there is a difference in the distribution of the genotype in patients with JIA and the healthy population. Methods: In 883 patients and 321 healthy controls the IL-12p40 promoter genotype was identified by ARMS-PCR. Results: There is no association of IL-12p40 pro polymorphism neither in patients with JIA compared to controls nor in subtypes of JIA compared to oligoarthritis. We found a non-significant tendency of a higher prevalence of the genotype pro1.1 in systemic arthritis (32.4 %) and in rheumatoid factor negative polyarthritis (30.5 %) and a lower pro1.1 genotype in persistent oligoarthritis (20.7 %) and in enthesitis-related arthritis (17 %). Likelihood of the occurrence of genotype IL12-p40 pro1.1 in patients with systemic arthritis (OR 1.722, CI 95 % 1.344-2.615, p 0.0129) and RF-negative polyarthritis (OR 1.576, CI 95 % 1.046-2.376, p 0.0367) compared to persistent oligoarthritis was significantly higher. This was also true for comparison of their homozygous genotypes IL-12p40 pro 1.1 and 2.2 in systemic arthritis (OR 1.779, CI 95 % 1.045-3.029, p 0.0338). However, in Bonferroni correction for multiple hypothesis this was not significant. Conclusion: A tendency of a higher prevalence of the genotype IL-12p40 pro1.1 in systemic arthritis and in rheumatoid factor negative polyarthritis was observed but not significant. Further investigations should be done to clarify the role IL-12p40 in the different subtypes of JIA. |
| Databáze: | OpenAIRE |
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