In-line filtration in very preterm neonates: a randomized controlled trial
| Autor: | Julien Pansiot, Thomas Storme, Andreas Capewell, Olivier Baud, Anne-Laure Virlouvet, Stéphane Rioualen, Emilie Guerriero, Valérie Biran, Artemis Toumazi, Aurélie Bourmaud, Marina Colella |
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| Přispěvatelé: | Neonatal intensive care unit [Paris], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-AP-HP Hôpital universitaire Robert-Debré [Paris], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Maladies neurodéveloppementales et neurovasculaires (NeuroDiderot (UMR_S_1141 / U1141)), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Paris (UP), Epidémiologie Clinique et Evaluation Economique Appliquées aux Populations Vulnérables (ECEVE (U1123 / UMR_S_1123)), Institut National de la Santé et de la Recherche Médicale (INSERM)-AP-HP Hôpital universitaire Robert-Debré [Paris], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université de Paris (UP), Pall Medical [Dreieich, Allemagne], Department of Pharmacy [Paris], Department of Neonatal Medicine [Brest], Centre Hospitalier Régional Universitaire de Brest (CHRU Brest), University of Geneva [Switzerland], This work was supported by a research Grant from from PALL Inc. PALL Inc. provided training for good clinical use of filters to medical and nurse staff, free of charge. PALL Inc. provided filters investigated in this study free of charge., Bodescot, Myriam, Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris Cité (UPCité), Université de Genève = University of Geneva (UNIGE) |
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
medicine.medical_specialty
Time Factors Critical Illness Inflammatory response lcsh:Medicine Paediatric research Article law.invention 03 medical and health sciences Prognostic markers [SDV.MHEP.PED] Life Sciences [q-bio]/Human health and pathology/Pediatrics 0302 clinical medicine Primary outcome Standard care Randomized controlled trial law Internal medicine medicine Humans 030212 general & internal medicine Infusions Intravenous lcsh:Science Inflammation [SDV.MHEP.PED]Life Sciences [q-bio]/Human health and pathology/Pediatrics Multidisciplinary ddc:618 business.industry lcsh:R Diagnostic markers Serum concentration Prognosis 3. Good health Very preterm Institutional repository Risk factors [SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie Infant Extremely Premature Cytokines In line filtration [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie lcsh:Q Inflammation Mediators business Filtration Vascular Access Devices 030217 neurology & neurosurgery |
| Zdroj: | Scientific Reports, Vol. 10, No 1 (2020) P. 5003 Scientific Reports, Vol 10, Iss 1, Pp 1-8 (2020) Scientific Reports Scientific Reports, Nature Publishing Group, 2020, 10 (1), pp.5003. ⟨10.1038/s41598-020-61815-4⟩ |
| ISSN: | 2045-2322 |
| DOI: | 10.1038/s41598-020-61815-4⟩ |
| Popis: | In-line filtration is increasingly used in critically-ill infants but its benefits, by preventing micro-particle infusion in very preterm neonates, remain to be demonstrated. We conducted a randomized controlled trial among very preterm infants allocated to receive either in-line filtration of all the intra-venous lines or standard care without filters. The primary outcome was differences greater than 20% in the median changes in pro-inflammatory cytokine serum concentrations measured at day 3 and day 8 (+/−1) using a Luminex multianalytic profiling technique. Major neonatal complications were analyzed as secondary predefined outcomes. We randomized 146 infants, assigned to filter (n = 73) or control (n = 73) group. Difference over 20% in pro-inflammatory cytokine concentration between day 3 and day 8 was not found statistically different between the two groups, both in intent-to-treat (with imputation) and per protocol (without imputation) analyses. The incidences of most of neonatal complications were found to be similar. Hence, this trial did not evidence a beneficial effect of in-line filtration in very preterm infants on the inflammatory response syndrome and neonatal morbidities. These data should be interpreted according to local standards in infusion preparation and central line management. |
| Databáze: | OpenAIRE |
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