24-Hour Control With a Latanoprost-Timolol Fixed Combination vs Timolol Alone
| Autor: | William C. Stewart, Symeon Lake, Jessica N. Jenkins, Athanasios I. Economou, K. Kaltsos, Anastasios G. P. Konstas |
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| Rok vydání: | 2006 |
| Předmět: |
Male
Intraocular pressure Evening genetic structures Visual Acuity Glaucoma Timolol Placebo chemistry.chemical_compound Double-Blind Method medicine Humans Prospective Studies Latanoprost Antihypertensive Agents Intraocular Pressure Morning business.industry Middle Aged medicine.disease eye diseases Circadian Rhythm Ophthalmology Treatment Outcome chemistry Anesthesia Prostaglandins F Synthetic Drug Therapy Combination Female sense organs Ophthalmic Solutions Latanoprost/timolol business Glaucoma Open-Angle medicine.drug |
| Zdroj: | Archives of Ophthalmology. 124:1553 |
| ISSN: | 0003-9950 |
| DOI: | 10.1001/archopht.124.11.1553 |
| Popis: | To evaluate 24-hour intraocular pressure (IOP) control with an evening-dosed latanoprost-timolol maleate fixed combination vs timolol alone in patients with primary open-angle glaucoma.After a medicine-free period, qualified patients were randomized to either placebo dosed in the morning with a latanoprost-timolol fixed combination dosed in the evening or timolol alone dosed twice daily for 8 weeks. Patients were then switched to the opposite treatment for 8 weeks. At baseline and at the end of each treatment period, patients underwent IOP measurements.Both treatments reduced the IOP from untreated baseline at each time point and for the 24-hour curve (P.001). When treatments were compared, the latanoprost-timolol fixed combination decreased the IOP more than timolol alone at each time point and for the 24-hour curve (2.9 mm Hg), and provided a lower absolute IOP at each time point (P.001) and for the range (fluctuation) in IOP (P = .003) and for the 24-hour curve. Several adverse effects were observed more often with the latanoprost-timolol fixed combination, including ocular stinging (P = .05), conjunctival hyperemia (P = .02), and ocular itching (P = .04).The evening-dosed latanoprost-timolol fixed combination may provide better IOP control than timolol alone over 24 hours and may demonstrate a narrower range of IOP fluctuation in patients with primary open-angle glaucoma. |
| Databáze: | OpenAIRE |
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