Comparison of the efficacy and safety of povidone‐iodine foam dressing (Betafoam), hydrocellular foam dressing (Allevyn), and petrolatum gauze for split‐thickness skin graft donor site dressing
| Autor: | Kap Sung Oh, Won Jai Lee, Kyung Ah Lee, Jong Won Rhie, Kyung Hee Kwak, Dae Hwan Park, Chang Sik Pak, Young Joon Jun, Tae Suk Oh |
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| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
Adult
Male medicine.medical_specialty Betafoam Adolescent Petrolatum Polyurethanes chemistry.chemical_element wound healing Dermatology Iodine Transplant Donor Site 030207 dermatology & venereal diseases 03 medical and health sciences Young Adult 0302 clinical medicine Split thickness skin graft Republic of Korea Medicine Humans 030212 general & internal medicine Prospective Studies Povidone-Iodine povidone‐iodine Aged Aged 80 and over split‐thickness skin graft integumentary system Emollients business.industry Original Articles Skin Transplantation Middle Aged Wound infection Bandages Surgery Safety profile chemistry Anti-Infective Agents Local Wound Infection Original Article Female donor site dressing business |
| Zdroj: | International Wound Journal |
| ISSN: | 1742-481X 1742-4801 |
| Popis: | We evaluated the efficacy and safety of a povidone-iodine (PVP-I) foam dressing (Betafoam) for donor site dressing versus a hydrocellular foam dressing (Allevyn) and petrolatum gauze. This prospective Phase 4 study was conducted between March 2016 and April 2017 at eight sites in Korea. A total of 106 consenting patients (aged ≥ 19 years, scheduled for split-thickness skin graft) were randomised 1:1:1 to PVP-I foam, hydrocellular, or petrolatum gauze dressings for up to 28 days after donor site collection. We assessed time to complete epithelialisation, proportion with complete epithelialisation at Day 14, and wound infection. Epithelialisation time was the shortest with PVP-I foam dressing (12.74 ± 3.51 days) versus hydrocellular foam dressing (16.61 ± 4.45 days; P = 0.0003) and petrolatum gauze (15.06 ± 4.26 days, P = 0.0205). At Day 14, 83.87% of PVP-I foam dressing donor sites had complete epithelialisation, versus 36.36% of hydrocellular foam dressing donor sites (P = 0.0001) and 55.88% of petrolatum gauze donor sites (P = 0.0146). There were no wound infections. Incidence rates of adverse events were comparable across groups (P = 0.1940). PVP-I foam dressing required less time to complete epithelialisation and had a good safety profile. |
| Databáze: | OpenAIRE |
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