A new quantitative index in the diagnosis of Parkinson syndrome by dopamine transporter single photon emission computed tomography

Autor: Tamaki Otani, Masafumi Harada, Yuishin Izumi, Wataru Sako, Shota Azane, Yoichi Otomi, Noritake Matsuda, Yamato Kunikane, Ryota Bando, Hideki Otsuka
Rok vydání: 2020
Předmět:
Adult
Male
Nortropanes
Functional dopamine transporter volume
Standardized uptake value
Single-photon emission computed tomography
030218 nuclear medicine & medical imaging
Diagnosis
Differential
Iodine Radioisotopes
03 medical and health sciences
0302 clinical medicine
Dopamine transporter SPECT
Dopamine
medicine
Cutoff
Humans
Radiology
Nuclear Medicine and imaging
Active dopamine transporter volume
Dopamine transporter
Aged
Retrospective Studies
Aged
80 and over
Tomography
Emission-Computed
Single-Photon
Dopamine Plasma Membrane Transport Proteins
Parkinson syndrome
medicine.diagnostic_test
biology
Receiver operating characteristic
business.industry
Phantoms
Imaging
Dopaminergic
Biological Transport
Parkinson Disease
General Medicine
Middle Aged
SUV
ROC Curve
030220 oncology & carcinogenesis
biology.protein
Female
Nuclear medicine
business
Emission computed tomography
medicine.drug
Zdroj: Annals of nuclear medicine. 35(4)
ISSN: 1864-6433
Popis: Objective Dopamine transporter single-photon emission computed tomography (DAT SPECT) has been widely used to diagnose Parkinson syndrome. Using the standardized uptake value (SUV) of DAT SPECT, we propose “functional dopamine transporter volume (f-DTV)” as a new quantitative index to evaluate the three-dimensional volume of functional dopamine transporters and assess its diagnostic ability in differentiating dopaminergic neurodegenerative diseases (dNDD) from non-dNDD. Methods Seventy-nine patients were enrolled (42 dNDD, 37 non-dNDD; 38 men; age, 24–88 years). We analyzed seven quantitative indices. The specific binding ratio (SBR) was calculated using a program specialized for DAT SPECT (SBR_Bolt). The SUVmax, SUVpeak, and SUVmean were calculated using a quantification program for bone SPECT. SBR_SUV was calculated by dividing striatal SUVmean by the average of background SUVmean. The cutoff value of the active dopamine transporter level was examined using three methods (threshold of 40% of SUVmax, SUV 2, and SUV 3) to calculate the active dopamine transporter volume (ADV). The f-DTV was calculated by multiplying ADV and SUVmean. We assessed the correlations between SBR_Bolt and SBR_SUV, and compared the mean value of each index between the dNDD and non-dNDD groups. The abilities of SBR_Bolt, SBR_SUV, SUVmax, SUVpeak, SUVmean, ADV, and f-DTV in differentiating dNDD from non-dNDD were determined by the area under the receiver operating curve (AUC) generated by the receiver operating characteristics analysis. Results The SBR_Bolt and SBR_SUV highly correlated each other (r = 0.71). The cutoff value of the active dopamine transporter level was determined as SUV 3. All seven quantitative indices showed lower values in the dNDD group than in the non-dNDD group, and the difference between the two groups was statistically significant (p
Databáze: OpenAIRE
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