Comparison of Subcutaneous and Intravenous Administration of a Solution of Aminoacids in Older Patients

Autor: Thierry Constans, Xavier Leverve, Monique Ferry
Přispěvatelé: Service de gériatrie, Centre hospitalier de Valence, Bioénergétique fondamentale et appliquée, Université Joseph Fourier - Grenoble 1 (UJF)-Institut National de la Santé et de la Recherche Médicale (INSERM), Gériatrie, Université de Tours, Université de Tours (UT), Hamant, Sarah
Rok vydání: 1997
Předmět:
Male
MESH: Nutritional Support
medicine.medical_specialty
MESH: Amino Acids
Injections
Subcutaneous
MESH: Solutions
Protein-Energy Malnutrition
MESH: Cross-Over Studies
Route of administration
MESH: Aged
80 and over
Older patients
[SDV.BBM] Life Sciences [q-bio]/Biochemistry
Molecular Biology
medicine
Humans
[SDV.BBM]Life Sciences [q-bio]/Biochemistry
Molecular Biology
Prospective Studies
Amino Acids
Nitrogen supplementation
Infusions
Intravenous
MESH: Infusions
Intravenous
Aged
Aged
80 and over
MESH: Aged
Baseline values
Osmole
Cross-Over Studies
MESH: Humans
Nutritional Support
business.industry
MESH: Injections
Subcutaneous
Mean age
Protein intake
MESH: Prospective Studies
MESH: Protein-Energy Malnutrition
MESH: Male
Surgery
Solutions
Anesthesia
Female
Geriatrics and Gerontology
business
MESH: Female
Zdroj: Journal of the American Geriatrics Society
Journal of the American Geriatrics Society, Wiley, 1997, 45 (7), pp.857-60
ISSN: 0002-8614
1532-5415
DOI: 10.1111/j.1532-5415.1997.tb01515.x
Popis: International audience; OBJECTIVE: To compare the plasma amino acid (AA) concentrations obtained by the infusion of an AA solution (660 mOsm/L, pH 7) using the subcutaneous (SC) with that using the intravenous (i.v.) route in older patients. DESIGN: A prospective, randomized, cross-over study. SETTING: A hospital geriatric ward. PARTICIPANTS: Six patients with a mean age of 84 years. MEASUREMENTS: The infusion of the AA solution (IV or SC) lasted 6 hours. Blood was sampled at 0, 2, 4, 6, 8, 10, 14, 18, and 24 hours from the start of the infusion to determine plasma AA level by the phenyl-isothiocyanate method. RESULTS: Compared with baseline values, plasma AA concentrations increased to a significantly higher level from the second to the tenth hour and from the second to the fourteenth hour during i.v. and SC infusions, respectively. Plasma AA levels did not differ between the two routes. SC infusion was well tolerated. CONCLUSION: Assuming that nutritional sufficiency is the desired result of plasma AA infusion, we conclude the SC route is well tolerated and offers the possibility of nitrogen supplementation for older patients over short periods of time, when oral protein intake is transiently insufficient or impossible, as a way to limit, but not to treat, protein-energy malnutrition.
Databáze: OpenAIRE
Externí odkaz: