Clinicopathological heterogeneity between primary and metastatic sites of gastroenteropancreatic neuroendocrine neoplasm

Autor: Cuihua Qi, Rong Lin, Qin Zhang, Huiying Shi, Chen Jiang, Hailing Yao
Jazyk: angličtina
Rok vydání: 2020
Předmět:
Male
Pathology
Gastroenterology
Metastasis
Ki-67 index
0302 clinical medicine
Medicine
030212 general & internal medicine
Neoplasm Metastasis
Synaptophysin (Syn)
Aged
80 and over
biology
Stomach
Chromogranin A
General Medicine
Middle Aged
Primary tumor
Neuroendocrine Tumors
medicine.anatomical_structure
030220 oncology & carcinogenesis
Chromogranin (CgA)
Female
Pancreas
lcsh:RB1-214
Adult
medicine.medical_specialty
Histology
Adolescent
Rectum
Pathology and Forensic Medicine
03 medical and health sciences
Young Adult
Stomach Neoplasms
Internal medicine
Intestinal Neoplasms
Biomarkers
Tumor
lcsh:Pathology
Humans
Pathological
Survival analysis
Aged
business.industry
Research
medicine.disease
Pancreatic Neoplasms
biology.protein
Heterogeneity
business
Gastroenteropancreatic neuroendocrine neoplasms (GEP-NENs)
Zdroj: Diagnostic Pathology, Vol 15, Iss 1, Pp 1-10 (2020)
Diagnostic Pathology
ISSN: 1746-1596
DOI: 10.1186/s13000-020-01030-x
Popis: Background Chromogranin A (CgA), synaptophysin (Syn) and the Ki-67 index play significant roles in diagnosis or the evaluation of the proliferative activity of gastroenteropancreatic neuroendocrine neoplasms (GEP-NENs). However, little is known about whether these biological markers change during tumor metastasis and whether such changes have effect on prognosis. Methods We analyzed 35 specimens of both primary and metastatic tumor from 779 patients who had been diagnosed as GEP-NENs at Wuhan Union Hospital from August 2011 to October 2019. The heterogeneity of CgA, Syn and Ki-67 index was evaluated by immunohistochemical analysis. Results Among these 779 patients, the three most common sites of NENs in the digestive tract were the pancreas, rectum and stomach. Metastases were found in 311 (39.9%) patients. Among the 35 patients with both primary and metastatic pathological specimens, differences in the Ki-67 level were detected in 54.3% of the patients, while 37.1% showed a difference in CgA and only 11.4% showed a difference in Syn. Importantly, due to the difference in the Ki-67 index between primary and metastatic lesions, the WHO grade was changed in 8.6% of the patients. In addition, a Kaplan–Meier survival analysis showed that patients with Ki-67 index variation had a shorter overall survival (p = 0.0346), while neither Syn variation nor CgA variation was related to patient survival (p = 0.7194, p = 0.4829). Conclusions Our data indicate that primary and metastatic sites of GEP-NENs may exhibit pathological heterogeneity. Ki-67 index variation is closely related to the poor prognosis of patients with tumor metastasis, but neither Syn variation nor CgA variation is related to patient prognosis. Therefore, clinicopathologic evaluation of the primary tumor and metastatic sites could be helpful for predicting the prognosis.
Databáze: OpenAIRE
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