Serological cytokine signature in paediatric patients with inflammatory bowel disease impacts diagnosis
| Autor: | Takeshi Tomomasa, Takumi Takizawa, Tomoko Nakazawa, Reiko Hatori, Seiichi Kagimoto, Takashi Ishige, Hirokazu Arakawa, Tomoko Hara, Maiko Tatsuki |
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| Rok vydání: | 2020 |
| Předmět: |
Male
Vascular Endothelial Growth Factor A 0301 basic medicine medicine.medical_specialty Adolescent medicine.medical_treatment Immunology lcsh:Medicine Disease Severity of Illness Index Inflammatory bowel disease Gastroenterology Article 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Internal medicine medicine Humans Child lcsh:Science Multidisciplinary business.industry Interleukins lcsh:R Area under the curve Interleukin Inflammatory Bowel Diseases medicine.disease Ulcerative colitis Vascular endothelial growth factor 030104 developmental biology Cytokine chemistry Cytokines Biomarker (medicine) Female lcsh:Q business Biomarkers 030217 neurology & neurosurgery |
| Zdroj: | Scientific Reports, Vol 10, Iss 1, Pp 1-11 (2020) Scientific Reports |
| ISSN: | 2045-2322 |
| DOI: | 10.1038/s41598-020-71503-y |
| Popis: | Endoscopy is a central tool for diagnosing and evaluating paediatric inflammatory bowel diseases (PIBD), but is too invasive to be frequently repeated in young children. Furthermore, it is challenging to distinguish Crohn’s disease (CD) from ulcerative colitis (UC) endoscopically. This study aimed to determine biomarkers useful for the diagnosis of PIBD. Cytokines, chemokines, and growth factors were quantified in the sera of 15 patients with CD or UC, at disease onset prior to treatment, and 26 age-matched controls. Correlation of cytokine levels with the paediatric CD activity index (PCDAI) and the paediatric UC activity index (PUCAI) was analysed. Interleukin (IL)-6, IL-13, IL-7, and vascular endothelial growth factor were higher in the CD group than in the UC group. The receiver operating characteristic curve analysis showed that IL-7 was a putative biomarker for distinguishing CD from UC (area under the curve: 0.94). Granulocyte–macrophage colony-stimulating factor was associated with PCDAI, and an IL-1 receptor antagonist, IL-6, and macrophage inflammatory protein-1β were associated with PUCAI. These findings indicate significant differences in cytokine signatures among patients with new-onset PIBD, which may improve accuracy in diagnosing PIBD. |
| Databáze: | OpenAIRE |
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