Dialkylammonium tert-Butylmethylphosphinites: Stable Intermediates for the Synthesis of P-Stereogenic Ligands
| Autor: | Xavier Verdaguer, Ernest Salomó, Amparo Prades, Antoni Riera |
|---|---|
| Přispěvatelé: | Universitat de Barcelona |
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
Phosphinite
010405 organic chemistry Stereochemistry Chemistry Organic Chemistry Ligands (Biochemistry) Boranes Lligands (Bioquímica) Borane 010402 general chemistry 01 natural sciences Combinatorial chemistry 0104 chemical sciences Stereocenter Catàlisi asimètrica chemistry.chemical_compound Nucleophile Compostos fosforosos Yield (chemistry) Melting point SN2 reaction Enantioselective catalysis Phosphorus compounds |
| Zdroj: | Recercat. Dipósit de la Recerca de Catalunya instname Dipòsit Digital de la UB Universidad de Barcelona |
| Popis: | The preparation of shelf-stable crystalline salts of tert-butylmethylphosphinous acid borane 1 is described. X-ray analysis of diisopropylammonium tert-butylmethylphosphinite borane 4 revealed the existence of a cyclic hydrogen-bond network in the solid state which accounts for the increased melting point and stability. Dialkylammonium phosphinite boranes are convenient precursors of the chiral tert-butylmethylphosphine fragment. Compound 4 can be directly employed in SN2@P reactions with different nucleophiles to yield valuable P-stereogenic intermediates and ligands. |
| Databáze: | OpenAIRE |
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