Inhibitory Effect of Bifemelane on Superoxide Generation by Activated Neutrophils Measured Using a Simple Chemiluminescence Method
Autor: | Akemi Sotomatsu, Shunsaku Hirai, Makoto Tanaka, Toshihiko Yoshida |
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Rok vydání: | 1994 |
Předmět: |
Xanthine Oxidase
Time Factors Neutrophils Hydrochloride In Vitro Techniques Pharmacology Biochemistry law.invention chemistry.chemical_compound Superoxides law medicine Humans Benzhydryl Compounds Bifemelane Opsonin Chemiluminescence Hypoxanthine Oxidase test Dose-Response Relationship Drug Superoxide Dismutase Chemistry Superoxide Zymosan General Medicine medicine.disease Antidepressive Agents N-Formylmethionine Leucyl-Phenylalanine Kinetics Hypoxanthines Luminescent Measurements Tetradecanoylphorbol Acetate Reperfusion injury |
Zdroj: | Free Radical Research. 21:371-376 |
ISSN: | 1029-2470 1071-5762 |
Popis: | We evaluated the effect of 4-(2-benzylphenoxy)-N-methylbutylamine hydrochloride (bifemelane hydrochloride) on superoxide production by human neutrophils using an MCLA-dependent chemiluminescence assay. Bifemelane hydrochloride dose-dependently inhibited superoxide production by neutrophils stimulated with phorbol myristate acetate, opsonized zymosan, or N-formyl-methionyl-leucyl-phenylalanine, while it had no effect on superoxide production by a hypoxanthine-xanthine oxidase system. These results indicate that bifemelane hydrochloride does not have a scavenging effect, but has an inhibitory effect on superoxide generation by neutrophils. Although this drug is commonly used for treating chronic cerebral infarction, it may also have a protective effect on acute ischemia/reperfusion injury. |
Databáze: | OpenAIRE |
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