The Family of Chloride Channel Regulator, Calcium-activated Proteins in the Feline Respiratory Tract: A Comparative Perspective on Airway Diseases in Man and Animal Models
| Autor: | Nancy A. Erickson, Lars Mundhenk, Achim D. Gruber |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Swine
040301 veterinary sciences Respiratory System Biology Cystic fibrosis 030308 mycology & parasitology Pathology and Forensic Medicine 0403 veterinary science Mice 03 medical and health sciences Chloride Channels medicine Animals Humans Secretion Respiratory system Submucosal glands 0303 health sciences CATS General Veterinary 04 agricultural and veterinary sciences medicine.disease Mucus Disease Models Animal medicine.anatomical_structure Immunology Cats Chloride channel Respiratory tract |
| Zdroj: | Journal of Comparative Pathology. 174:39-53 |
| ISSN: | 0021-9975 |
| Popis: | Members of the chloride channel regulator, calcium-activated (CLCA) family are considered to be modifiers in inflammatory, mucus-based respiratory conditions such as asthma and cystic fibrosis. Previous work has shown substantial differences between human and murine CLCA orthologues that limit the value of mouse models. As an alternative, the cat is an unfamiliar but powerful model of human asthma. We therefore characterized the expression profiles of CLCA proteins in the feline respiratory tract. Identical to other species, the feline CLCA1 protein was immunohistochemically localized to virtually all goblet cells and found to be secreted into the mucus. However, it was not detected in submucosal glands where it is expressed in other species. In contrast to all other species studied to date, feline CLCA2 was not found in submucosal glands or any other airway cells. Similar to mice, but in contrast to man and pigs, the feline respiratory tract was devoid of CLCA4 expression. In the airways of asthmatic cats, CLCA1 was strongly overexpressed, similar to human patients. Therefore, despite some similarities in CLCA1 protein expression and secretion, substantial differences were identified between several feline CLCA family members and their respective orthologues in man, mice and pigs, which must be considered in comparative medicine. |
| Databáze: | OpenAIRE |
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