Protein interaction networks as starting points to identify novel antimicrobial drug targets
| Autor: | Roya Zoraghi, Neil E. Reiner |
|---|---|
| Rok vydání: | 2013 |
| Předmět: |
Microbiology (medical)
Drug Bacteria Drug discovery media_common.quotation_subject Computational biology Biology Bioinformatics Microbiology Antimicrobial drug Infectious Diseases Anti-Infective Agents Protein Interaction Networks Drug Discovery Identification (biology) Protein Interaction Maps Antibacterial drug Host protein Protein Interaction Map media_common |
| Zdroj: | Current Opinion in Microbiology. 16:566-572 |
| ISSN: | 1369-5274 |
| DOI: | 10.1016/j.mib.2013.07.010 |
| Popis: | Novel classes of antimicrobials are needed to address the challenge of multidrug-resistant bacteria. Current bacterial drug targets mainly consist of specific proteins or subsets of proteins without regard for either how these targets are integrated in cellular networks or how they may interact with host proteins. However, proteins rarely act in isolation, and the majority of biological processes are dependent on interactions with other proteins. Consequently, protein-protein interaction (PPI) networks offer a realm of unexplored potential for next-generation drug targets. In this review, we argue that the architecture of bacterial or host-pathogen protein interactomes can provide invaluable insights for the identification of novel antibacterial drug targets. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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