The Epidemiology of Irritable Bowel Syndrome in the US Military: Findings from the Millennium Cohort Study
| Autor: | Mark S. Riddle, Marleen M. Welsh, Tomoko I. Hooper, Edward J. Boyko, Chad K. Porter, Chiping Nieh, Gary D. Gackstetter |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
Adult
Male medicine.medical_specialty MEDLINE Cohort Studies Irritable Bowel Syndrome 03 medical and health sciences 0302 clinical medicine Risk Factors Epidemiology medicine Humans Longitudinal Studies 030212 general & internal medicine Functional GI Disorders Psychiatry health care economics and organizations Irritable bowel syndrome Hepatology business.industry Gastroenterology social sciences Middle Aged medicine.disease United States digestive system diseases humanities Military personnel Military Personnel Millennium Cohort Study (United States) population characteristics Female 030211 gastroenterology & hepatology business Cohort study |
| Zdroj: | The American Journal of Gastroenterology |
| ISSN: | 0002-9270 |
| DOI: | 10.1038/ajg.2015.386 |
| Popis: | OBJECTIVES: Functional gastrointestinal disorders occur more frequently among deployed veterans, although studies evaluating the relative impact of risk factors, including stress and antecedent infectious gastroenteritis (IGE), are limited. We examined risk factors for new-onset irritable bowel syndrome (IBS) among active duty participants in the military's Millennium Cohort Study. METHODS: Medical encounter data from 2001 to 2009, limited to Cohort members on active duty, were used to identify incident IBS cases (any and highly probable). IGE was identified using medical encounter or self-report. Covariate data were obtained from the Millennium Cohort Study surveys and analyzed using Cox proportional hazards methods. RESULTS: Overall, 41,175 Cohort members met the eligibility criteria for inclusion and 314 new-onset cases of IBS were identified among these. Significant risk factors (adjusted hazard ratio, 95% confidence interval) included antecedent IGE (2.05, 1.53–2.75), female gender (1.96, 1.53–2.52), number of life stressors (1: 1.82, 1.37–2.41; 2: 2.86, 2.01–4.06; 3+: 6.69, 4.59–9.77), and anxiety syndrome (1.74, 1.17–2.58). Limited to highly probable IBS, a stronger association with antecedent IGE was observed, particularly when based on medical encounter records (any IGE: 2.20, 1.10–4.43; medical encounter IGE only: 2.84, 1.33–6.09). Precedent anxiety or depression and IGE interacted with increased IBS risk compared with IGE alone. CONCLUSIONS: These results confirm previous studies on the association between sociodemographic or life stressors and IBS. IGE was significantly associated with IBS risk. Whether deployed or not, US service members often encounter repeated exposure to high levels of stress, which, combined with other environmental factors such as IGE, may result in long-term debilitating functional gastrointestinal disorders. |
| Databáze: | OpenAIRE |
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