Optical coherence tomography as a diagnostic aid to visual inspection and colposcopy for preinvasive and invasive cancer of the uterine cervix
| Autor: | Pedro F. Escobar, Jennifer Brainard, S. Tisci, N. J. Tresser, Felix I. Feldchtein, L. B. Rojas, Jerome L. Belinson, Jennifer S. Smith, Luis Rojas-Espaillat, Christine L. Enerson |
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| Rok vydání: | 2006 |
| Předmět: |
Adult
medicine.medical_specialty genetic structures Adolescent Uterine Cervical Neoplasms Cervix Uteri Cervical intraepithelial neoplasia Sensitivity and Specificity Optical coherence tomography Biopsy medicine Humans Aged Gynecology Colposcopy Cervical cancer medicine.diagnostic_test Receiver operating characteristic business.industry Obstetrics and Gynecology Middle Aged medicine.disease Uterine Cervical Dysplasia Visual inspection Oncology Dysplasia Female Radiology business Tomography Optical Coherence |
| Zdroj: | International journal of gynecological cancer : official journal of the International Gynecological Cancer Society. 16(5) |
| ISSN: | 1048-891X |
| Popis: | The purpose of this study was to determine the sensitivity and specificity of optical coherence tomography (OCT) under two well-defined clinical settings. First, as an aid to cervical cancer screening, using visual inspection with acetic acid (VIA) in low-resource settings, and the second, as an adjunct to the traditional management of abnormal cervical cytology with colposcopy and biopsy. Patients referred for colposcopy withor = atypical squamous cells of undetermined significance were accrued for the study. Each subject underwent VIA and colposcopy. OCT was performed in all VIA- and colposcopy-positive areas and at the squamocolumnar junction in all four quadrants. The sensitivity of VIA foror = cervical intraepithelial neoplasia 2 was 76% (95% CI 58-88). When OCT was applied to VIA as a secondary screen, the specificity improved from 34% (95% CI 27-41) to 61% (95% CI 60-74). With liberal diagnostic criteria for the majority of the colposcopy examinations, OCT showed an even greater relative improvement in specificity. OCT proved to be a fair diagnostic modality (receiver operating characteristic curve 0.73) adjunctive to VIA and colposcopy. On the basis of the above findings, we believe that this technology could potentially show greatest utility in the management of cervical dysplasia in low-resource settings where a single episode of care is most desirable. |
| Databáze: | OpenAIRE |
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