Correlation of Transcranial Color Doppler to N20 Somatosensory Evoked Potential Detects Ischemic Penumbra in Subarachnoid Hemorrhage
| Autor: | Elena Forini, Paolo Zanatta, Ilaria Morghen, Piero Di Pasquale, Enrico Bosco |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2011 |
| Předmět: |
medicine.medical_specialty
Subarachnoid hemorrhage cerebral blood flow Perfusion scanning transcranial color-doppler Article Internal medicine medicine.artery medicine ischemic penumbra cardiovascular diseases Subarachnoid haemorrhage business.industry brain perfusion Penumbra Blood flow medicine.disease nervous system diseases Transcranial Doppler Psychiatry and Mental health somatosensory evoked potentials brain vascular resistances Neurology Cerebral blood flow Somatosensory evoked potential Anesthesia Middle cerebral artery Cardiology Neurology (clinical) business |
| Zdroj: | The Open Neurology Journal |
| ISSN: | 1874-205X |
| Popis: | Background: Normal subjects present interhemispheric symmetry of middle cerebral artery (MCA) mean flow velocity and N20 cortical somatosensory evoked potential (SSEP). Subarachnoid haemorrhage (SAH) can modify this pattern, since high regional brain vascular resistances increase blood flow velocity, and impaired regional brain perfusion reduces N20 amplitude. The aim of the study is to investigate the variability of MCA resistances and N20 amplitude between hemispheres in SAH. Methods: Measurements of MCA blood flow velocity (vMCA) by transcranial color-Doppler and median nerve SSEP were bilaterally performed in sixteen patients. MCA vascular changes on the compromised hemisphere were calculated as a ratio of the reciprocal of mean flow velocity (1/vMCA) to contralateral value and correlated to the simultaneous variations of interhemispheric ratio of N20 amplitude, within each subject. Data were analysed with respect to neuroimaging of MCA supplied areas. Results: Both interhemispheric ratios of 1/vMCA and N20 amplitude were detected >0.65 (p 0.65 if penumbra disappeared. The two ratios no longer correlated after structural lesion developed, as N20 detected in the damaged side remained pathological (ratio 0.65), suggesting a luxury perfusion. Conclusion: Variations of interhemispheric ratios of MCA resistance and cortical N20 amplitude correlate closely in SAH and allow identification of the reversible ischemic penumbra threshold, when both ratios become |
| Databáze: | OpenAIRE |
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