Mitochondrial reactive oxygen species: the effects of mitochondrial ascorbic acid vs untargeted and mitochondria-targeted antioxidants
| Autor: | Mara Fiorani, Orazio Cantoni, Andrea Guidarelli |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Mitochondrial ROS
ascorbic acid mitochondrial antioxidants mitochondrial transport of ascorbic acid Ascorbic Acid Mitochondrion Antioxidants 030218 nuclear medicine & medical imaging 03 medical and health sciences 0302 clinical medicine Animals Humans Radiology Nuclear Medicine and imaging chemistry.chemical_classification Reactive oxygen species Radiological and Ultrasound Technology Ascorbic acid Mitochondria Oxidative Stress Biochemistry chemistry 030220 oncology & carcinogenesis Reactive Oxygen Species Mitochondria targeted |
| Zdroj: | International Journal of Radiation Biology. 97:1055-1062 |
| ISSN: | 1362-3095 0955-3002 |
| Popis: | Mitochondria represent critical sites for reactive oxygen species (ROS) production, which dependent on concentration is responsible for the regulation of both physiological and pathological processes.Antioxidants in mitochondria regulate the redox balance, prevent mitochondrial damage and dysfunction and maintain a physiological ROS-dependent signaling. The aim of the present review is to provide critical elements for addressing this issue in the context of various pharmacological approaches using antioxidants targeted or non-targeted to mitochondria. Furthermore, this review focuses on the mitochondrial antioxidant effects of ascorbic acid (AA), providing clues on the complexities associated with the cellular uptake and subcellular distribution of the vitamin.Antioxidants that are not specifically targeted to mitochondria fail to accumulate in significant amounts in critical sites of mitochondrial ROS production and may eventually interfere with the ensuing physiological signaling. Mitochondria-targeted antioxidants are more effective, but are expected to interfere with the mitochondrial ROS-dependent physiologic signaling. AA promotes multiple beneficial effects in mitochondria. The complex regulation of vitamin C uptake in these organelles likely contributes to its versatile antioxidant response, thereby providing a central role to the vitamin for adequate control of mitochondrial dysfunction associated with increased mitochondrial ROS production. |
| Databáze: | OpenAIRE |
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