Clinical and imaging features distinguishing Susac syndrome from primary angiitis of the central nervous system
| Autor: | Alejandro Kohler, Naomi Arakaki, M.P. Fiol, Julian N Acosta, Victoria Fernandez, Mariano Marrodan, J. Correale, Sebastian F. Ameriso, E. Carnero Contentti, Lucas Alessandro |
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| Rok vydání: | 2018 |
| Předmět: |
Adult
Male Pediatrics medicine.medical_specialty Ataxia Susac Syndrome Central nervous system Corpus callosum Diagnosis Differential 03 medical and health sciences 0302 clinical medicine Recurrence Auditory disturbances Medicine Humans Cognitive Dysfunction Cognitive impairment Vasculitis Central Nervous System Retrospective Studies 030203 arthritis & rheumatology Immunosuppression Therapy business.industry Brain Mean age medicine.disease medicine.anatomical_structure Neurology Auditory Perception Female Neurology (clinical) medicine.symptom business Vasculitis 030217 neurology & neurosurgery Biomarkers Follow-Up Studies |
| Zdroj: | Journal of the neurological sciences. 395 |
| ISSN: | 1878-5883 |
| Popis: | To assess clinical and/or imaging features useful to distinguish between Susac syndrome (SuS) and primary angiitis of central nervous system (PACNS).Multicenter retrospective analysis of two cohorts of Argentine patients diagnosed with SuS and PACNS.13 patients diagnosed with SuS (6 women and 7 men, mean age 35 ± 10 years) and 15 with PACNS (10 women and 5 men, mean age 44 ± 18 years) were analyzed. Cognitive impairment (11 out of 13 patients vs. 5 out of 15, p = .006), ataxia (7 out of 13 vs. 2 out of 15, p = .042) and auditory disturbances (7 out of 13 vs. 0 out of 15, p = .003) were more frequent in SuS patients; whereas seizures were more frequent in PACNS patients (8 out of 15 vs. 1 out of 13, p = .035). On MRI, corpus callosum (CC) involvement was observed more often in SuS, with abnormalities in CC genu, in 13 out of 13 SuS patients vs. only 2 out of 15 PACNS patients (p .001); in CC body these were present in 13 out of 13 SuS patients vs. 1 out of 15 PACNS patients, (p .001); and in CC splenium in 12 out of 13 Sus patients vs. 1 of 15 PACNS, p .001). Cortical lesions were more frequent in PACNS patients (10 out of 15 vs. 3 out of 13 SuS patients, p = .02), as were hemorrhages (5 out of 15 vs. 0 out of 13 SuS, p = .04) and multiple basal ganglia infarcts (7 out of 15 vs. 1 out of 13 Sus, p = .037).Specific clinical and/or MRI findings may help distinguish SuS from PACNS with potential therapeutic implications. |
| Databáze: | OpenAIRE |
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