Glucose metabolism before and after treatment in patients with acromegaly
| Autor: | Marta García Mouriz, Nerea Eguílaz Esparza, Ander Ernaga Lorea, María Dolores Ollero García-Agulló, Ana Iriarte Beroiz, Rosa María Rodríguez Erdozain |
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| Rok vydání: | 2017 |
| Předmět: |
Adenoma
Adult Blood Glucose Male medicine.medical_specialty 030209 endocrinology & metabolism Carbohydrate metabolism Gastroenterology 03 medical and health sciences 0302 clinical medicine Pituitary adenoma Internal medicine Diabetes mellitus Acromegaly medicine Humans In patient Prediabetes Insulin-Like Growth Factor I Aged Glucose Metabolism Disorders Glycated Hemoglobin Medical treatment business.industry Middle Aged medicine.disease Tumor Burden Glucose Endocrinology Carbohydrate Metabolism Female Growth Hormone-Secreting Pituitary Adenoma business 030217 neurology & neurosurgery After treatment Follow-Up Studies |
| Zdroj: | Endocrinología, Diabetes y Nutrición (English ed.). 64:363-368 |
| ISSN: | 2530-0180 |
| DOI: | 10.1016/j.endien.2017.05.007 |
| Popis: | Introduction The aim of this study was to ascertain the prevalence of carbohydrate changes in patients diagnosed with acromegaly, and to evaluate what happens two years after treatment. It was also intended to assess which factors are associated to the occurrence of such changes. Material and methods Sixty-six patients diagnosed with acromegaly at our center were enrolled and divided into groups with normal glucose metabolism, prediabetes, and diabetes. After 2 years of treatment of acromegaly, prevalence carbohydrate changes was assessed again depending on the patient condition (cured, controlled with medical treatment, or uncontrolled). Results At the time of diagnosis of acromegaly, 27.3% of the patients had diabetes (n = 18), 39.4% had prediabetes (n = 26), and 33.3% had no changes (n = 22). Significant differences were found in IGF-1 and z -score of IGF-1 (median of 18.1 in diabetics and 10.6 in non-diabetics, p = 0.005). Two years after treatment, there was a significant decrease in the prevalence of diabetes and prediabetes in cured patients (from 29.2% to 8.3% and from 45.8% to 16.7%, respectively, p = 0.003), but not in patients controlled with medical treatment or not controlled. Conclusion At our center, 66.6% of patients with acromegaly had changes in carbohydrate metabolism at diagnosis, with a prevalence of diabetes of 27.3%. Two years after treatment of acromegaly, prevalence of diabetes and prediabetes decreased in cured patients. |
| Databáze: | OpenAIRE |
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