Diagnostic value of 8-isoprostane and transforming growth factor-β in bronchial asthma patients
| Autor: | Ayman S. El-dib, Amgad Frahat, Yousef Mansour, Doaa Alsed |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Inflammation airflow obstruction medicine.disease_cause Lipid peroxidation 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine medicine Asthma lcsh:RC705-779 medicine.diagnostic_test business.industry lcsh:Medical emergencies. Critical care. Intensive care. First aid hyperreponsiveness lcsh:Diseases of the respiratory system lcsh:RC86-88.9 asthma medicine.disease respiratory tract diseases 030104 developmental biology Bronchoalveolar lavage 030228 respiratory system chemistry inflammation 8-iso-prostaglandin F2α Immunology biomarker Biomarker (medicine) medicine.symptom business Airway Oxidative stress Transforming growth factor |
| Zdroj: | The Egyptian Journal of Bronchology, Vol 12, Iss 3, Pp 295-302 (2018) |
| ISSN: | 2314-8551 1687-8426 |
| DOI: | 10.4103/ejb.ejb_18_17 |
| Popis: | Background Asthma is an airway inflammatory disease with functional and structural changes, leading to bronchial hyperreponsiveness and airflow obstruction. 8-Isoprostane (8-iso-PGF2α) is considered a marker of oxidative stress specific to lipid peroxidation, transforming growth factor β1 (TGFβ1) as an important fibrogenic and immunomodulatory factor known to induce structural changes associated with asthma. Objective We aimed to study the diagnostic value of 8-iso-PGF2α and TGFβ1 in asthmatic patients. Patients and methods Samples of serum and bronchoalveolar lavage fluid from 40 asthmatic patients (20 moderate and 20 severe) and 10 healthy volunteers were assessed for their levels of 8-iso-PGF2α and TGFβ1. Results Bronchoalveolar lavage 8-iso-PGF2α and TGFβ1 was higher in asthmatic patients. It was significantly increased with increased asthma severity. Conclusion Increased levels of TGFβ1 and 8-iso-PGF2α is associated with disease severity. However, there is need for continued exploration on the mechanisms responsible for these structural changes. |
| Databáze: | OpenAIRE |
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