Evaluation of the hemostatic and histopathological effects of Ankaferd Blood Stopper in experimental liver injury in rats
| Autor: | Ayberk Oktay, Ahmet Akkoç, Kivanc Inan, Nihal Y. Gul Satar, Ayse Topal |
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| Přispěvatelé: | Uludağ Üniversitesi/Veterinerlik Fakültesi/Cerrahi Bölümü., Uludağ Üniversitesi/Veterinerlik Fakültesi/Patoloji Anabilim Dalı., Satar, Nihal Y.Gül, Akkoç, Ahmet, Oktay, Ayberk, Topal, Ayşe, İnan, Kıvanç |
| Jazyk: | angličtina |
| Rok vydání: | 2013 |
| Předmět: |
Unclassified drug
Rats sprague-dawley medicine.medical_treatment Hematocrit Liver injury Gastroenterology Animal tissue Wedge resection Bleeding time chemistry.chemical_compound In-vitro Experimental rat Ankaferd blood stopper Saline Priority journal medicine.diagnostic_test Cellulose oxidized Liver resection General Medicine Hematology Liver Female Peritoneum adhesion medicine.medical_specialty Efficacy Oxidized cellulose Histopathology Adhesion formation Article Experimental Blood loss Hemostasis surgical Internal medicine medicine Animals Ankaferd Blood Stopper Gastrointestinal Hemorrhage Endoscopic Hemostasis Animal model Animal experiment Blood loss surgical Hemostasis business.industry Bleeding Agents Plant extracts medicine.disease Hemostatic agent Nonhuman Surgery Rats Oxidized regenerated cellulose chemistry Rat Liver regeneration business Controlled study Model Tissue adhesions |
| Popis: | We studied the hemostatic and histopathological effects, and intra-abdominal adhesion scores of a new hemostatic agent, Ankaferd Blood Stopper (ABS), in an experimental liver injury model and compared it with regenerated oxidized cellulose. Thirty-six rats were randomly assigned to ABS, oxidized cellulose (Surgicel), and control groups (n=12, each). A wedge resection was performed on the left medial lobe of the liver. In the ABS group the liver surface was sprayed with ABS, whereas in the Surgicel group the liver was covered with double-layered oxidized cellulose. In the control group, saline solution was sprayed on the cut surface. The mean bleeding time was shorter in the ABS (23.08 +/- 6.99s) and Surgicel groups (47.91 +/- 8.21s) than in the control group (223.42 +/- 57.83s). No significant difference was found in the ABS and Surgicel groups in terms of preoperative and postoperative hematocrit (hct) values (P>0.05). Whereas there was no significant difference on day 7 (P>0.05), total adhesion score of ABS group was lower than both Surgicel (P |
| Databáze: | OpenAIRE |
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