Efficient, Transition Metal Mediated, Sequential, Two- and Three-Component Coupling Reactions for the Synthesis of Highly Substituted Five-Membered Ring Carbocycles

Autor:	Didier Bouyssi, Nicolas Coia, Geneviève Balme
Rok vydání:	2007
Předmět:	Component (thermodynamics) Chemistry Organic Chemistry chemistry.chemical_element General Medicine Ring (chemistry) Combinatorial chemistry Coupling reaction Transmetalation Transition metal Intramolecular force Michael reaction Organic chemistry Physical and Theoretical Chemistry Palladium
Zdroj:	ChemInform. 38
ISSN:	1522-2667 0931-7597
DOI:	10.1002/chin.200743063
Popis:	A Cu-catalysed method for the preparation of highly substituted methylenecyclopentanes, through a sequence involving a Michael addition of stabilized enolates to activated enynes followed by an intramolecular carbocupration reaction, is presented. This method was also successfully combined with a Pd-mediated coupling reaction to perform a new three-component reaction through a transmetallation pathway on the vinylcopper intermediate. (© Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2007)
Databáze:	OpenAIRE
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