The Longitudinal Epidemiologic Assessment of Diabetes Risk (LEADR): Unique 1.4 M patient Electronic Health Record cohort
| Autor: | Wilson D. Pace, David C. Kaelber, Rebecca Birch, Xuanping Zhang, Maurice C. Johnson, Holly L. Sawyer, Krista K. Proia, Sunitha Mathew, Keith D. Umbel, Gerald Pulver, Deborah B. Rolka, Russell E. Mardon, Howard Fishbein, Jennifer Poling, Meda E. Pavkov, Giuseppina Imperatore, Kai McKeever Bullard, Karen R. Siegel, Yiling J. Cheng, Edward W. Gregg, Sundar S. Shrestha |
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| Rok vydání: | 2020 |
| Předmět: |
Adult
Male medicine.medical_specialty Diabetes risk Adolescent endocrine system diseases Psychological intervention Risk Assessment Cohort Studies Prediabetic State 03 medical and health sciences 0302 clinical medicine Risk Factors Epidemiology Health care medicine Electronic Health Records Humans Longitudinal Studies 030212 general & internal medicine Risk factor Aged Retrospective Studies business.industry Health Policy Public health nutritional and metabolic diseases Evidence-based medicine Middle Aged Diabetes Mellitus Type 2 Family medicine Cohort Female business 030217 neurology & neurosurgery |
| Zdroj: | Healthcare. 8:100458 |
| ISSN: | 2213-0764 |
| Popis: | Background The Longitudinal Epidemiologic Assessment of Diabetes Risk (LEADR) study uses a novel Electronic Health Record (EHR) data approach as a tool to assess the epidemiology of known and new risk factors for type 2 diabetes mellitus (T2DM) and study how prevention interventions affect progression to and onset of T2DM. We created an electronic cohort of 1.4 million patients having had at least 4 encounters with a healthcare organization for at least 24-months; were aged ≥18 years in 2010; and had no diabetes (i.e., T1DM or T2DM) at cohort entry or in the 12 months following entry. EHR data came from patients at nine healthcare organizations across the U.S. between January 1, 2010–December 31, 2016. Results Approximately 5.9% of the LEADR cohort (82,922 patients) developed T2DM, providing opportunities to explore longitudinal clinical care, medication use, risk factor trajectories, and diagnoses for these patients, compared with patients similarly matched prior to disease onset. Conclusions LEADR represents one of the largest EHR databases to have repurposed EHR data to examine patients’ T2DM risk. This paper is first in a series demonstrating this novel approach to studying T2DM. Implications Chronic conditions that often take years to develop can be studied efficiently using EHR data in a retrospective design. Level of evidence While much is already known about T2DM risk, this EHR's cohort's 160 M data points for 1.4 M people over six years, provides opportunities to investigate new unique risk factors and evaluate research hypotheses where results could modify public health practice for preventing T2DM. |
| Databáze: | OpenAIRE |
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