Autosomal Dominant Polycystic Kidney Disease Transplant Recipients After Kidney Transplantation: A Single-center Experience

Autor: Balázs Nemes, D. Kovács, Lóránt Illésy, A.B.L. Asztalos, Réka P. Szabó
Rok vydání: 2017
Předmět:
Adult
Male
medicine.medical_specialty
Pathology
Gastrointestinal Diseases
Urinary system
Perforation (oil well)
030232 urology & nephrology
Autosomal dominant polycystic kidney disease
030230 surgery
Klinikai orvostudományok
urologic and male genital diseases
Single Center
Gastroenterology
03 medical and health sciences
Postoperative Complications
0302 clinical medicine
Internal medicine
Prevalence
medicine
Humans
Survival rate
Kidney transplantation
Retrospective Studies
Transplantation
Kidney
urogenital system
business.industry
Graft Survival
Retrospective cohort study
Orvostudományok
Middle Aged
Polycystic Kidney
Autosomal Dominant
medicine.disease
Kidney Transplantation
female genital diseases and pregnancy complications
Survival Rate
medicine.anatomical_structure
Urinary Tract Infections
Kidney Failure
Chronic
Female
Surgery
business
Zdroj: Transplantation Proceedings. 49:1522-1525
ISSN: 0041-1345
DOI: 10.1016/j.transproceed.2017.06.014
Popis: Kidney transplantation is indicated for end-stage renal disease. Autosomal dominant polycystic kidney disease (ADPKD) causes structural degeneration of the kidney and eventually becomes end-stage renal disease. ADPKD patients usually have several renal and nonrenal complications. We analyzed our kidney transplantation activities between 1991 and 2010 regarding ADPKD. We followed up with patients to December 31, 2016. Data were collected as patient and graft survival rates, the prevalence of polycystic manifestation of the gastrointestinal tract and other organs, and the attendance of urinary tract infection. Among the 734 kidney transplantations, 10.9% (n = 80) had an ADPKD. Four patients (5%) had diverticulum perforation. The prevalence of post-transplantation urinary tract infection was higher in ADPKD patients (55.9%) compared to non-ADPKD patients (44.1%). The 1-, 3-, and 5-year overall survival rates in ADPKD recipients versus non-ADPKD patients are 77.5%, 70.0%, and 67.5% versus 86.4%, 83.0%, and 80.1%, respectively. Patients with ADPKD were transplanted at an elder age compared to others (median: 47.5 years vs. 39.9 years). Female patients had longer graft survival times than males. ADPKD implies multiple cystic degeneration of the kidneys; however, it can cause structural degeneration in other organs. It is typical for ADPKD patients to have an acute abdominal-like syndrome. Immunosuppressive drugs can hide the clinical picture, which makes early diagnosis difficult.
Databáze: OpenAIRE
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