Intravaginal and Intranasal Immunizations Are Equally Effective in Inducing Vaginal Antibodies and Conferring Protection against Vaginal Candidiasis
| Autor: | Antonietta Girolamo, Antonio Cassone, Daniela Adriani, M. Boccanera, Flavia De Bernardis |
|---|---|
| Rok vydání: | 2002 |
| Předmět: |
Cholera Toxin
medicine.medical_treatment Immunology Enzyme-Linked Immunosorbent Assay Microbiology Vaginal disease Candida albicans medicine Animals Administration Intranasal Antibodies Fungal Candidiasis Vulvovaginal Vaginitis Fungal vaccine biology medicine.disease biology.organism_classification Fungal antigen Rats Administration Intravaginal Infectious Diseases medicine.anatomical_structure Microbial Immunity and Vaccines Vagina Female Immunization Parasitology Intravaginal administration Fungal Vaccines Adjuvant |
| Zdroj: | Infection and Immunity. 70:2725-2729 |
| ISSN: | 1098-5522 0019-9567 |
| DOI: | 10.1128/iai.70.5.2725-2729.2002 |
| Popis: | Oophorectomized, estrogen-treated rats were immunized by the intravaginal or intranasal route with a mannoprotein extract (MP) or secreted aspartyl proteinases (Sap) of Candida albicans , with or without cholera toxin as a mucosal adjuvant. Both routes of immunization were equally effective in (i) inducing anti-MP and anti-Sap vaginal antibodies and (ii) conferring a high degree of protection against the vaginal infection by the fungus. These data suggest that appropriate fungal antigens and adjuvant can be used to protect against candidal vaginitis, by either route. |
| Databáze: | OpenAIRE |
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