Epidemiology of chronic Pseudomonas aeruginosa infections in cystic fibrosis
| Autor: | Joachim Greipel, B. Fiedler, J Bosshammer, Dietmar Grothues, Ute Römling, Burkhard Tümmler, von der Hardt H |
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| Rok vydání: | 1994 |
| Předmět: |
Male
Pancreatic disease Adolescent Cystic Fibrosis Genotype medicine.disease_cause Cystic fibrosis Microbiology medicine Immunology and Allergy Humans Colonization Pseudomonas Infections Typing Longitudinal Studies Child Phage typing Molecular Epidemiology Pyocins biology Pseudomonas aeruginosa Chromosomes Bacterial biology.organism_classification medicine.disease Bacterial Typing Techniques Infectious Diseases Phenotype Immunology Chronic Disease Female Polymorphism Restriction Fragment Length Pseudomonadaceae |
| Zdroj: | The Journal of infectious diseases. 170(6) |
| ISSN: | 0022-1899 |
| Popis: | The epidemiology of chronic colonization of airways with Pseudomonas aeruginosa was monitored in 44 patients with cystic fibrosis (CF) by DraI/SpeI macrorestriction analyses of 489 isolates. Sequential P. aeruginosa isolates (144) that had been collected from 32 CF patients overor = 2.5 years were investigated, and 12 patients were followed for 8 years after onset of colonization. Forty-eight different genotypes were uncovered from 481 typeable isolates. Ten genotypes were found in1 unrelated CF patient. The 6 most frequent clones were identified in 58% of isolates. Ten of the 12 patients monitored for 8 years were harboring their initially acquired P. aeruginosa clone at all times, with subtle shifts of fragment patterns indicating subclonal variation. During colonization, the bacteria gradually lost pyocin and phage typing responses, supporting the view that genotypically discordant P. aeruginosa strains develop a common phenotype. |
| Databáze: | OpenAIRE |
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