Toxicological Profile of the Aqueous Extract of Tectona grandis L.F. (Verbenaceae) Leaves: A Medicinal Plant Used in the Treatment of Typhoid Fever in Traditional Cameroonian Medicine
| Autor: | Siméon Pierre Fodouop Chegaing, Louis-Claire Ndel Famen, Huguette Bocanestine Laure Feudjio, Norbert Kodjio, Jean Baptiste Sokoudjou, Dieudonné Pascal Djamen Chuisseu, Gabriel Tchuente Kamsu, Donatien Gatsing |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Pharmacology
biology Traditional medicine Article Subject 010405 organic chemistry business.industry Lethal dose Toxicology biology.organism_classification medicine.disease 01 natural sciences Acute toxicity Typhoid fever 0104 chemical sciences 010404 medicinal & biomolecular chemistry Phytomedicine Therapeutic index Tectona RA1190-1270 Toxicity Toxicology. Poisons Medicine medicine.symptom business Weight gain |
| Zdroj: | Journal of Toxicology, Vol 2021 (2021) |
| ISSN: | 1687-8191 |
| DOI: | 10.1155/2021/6646771 |
| Popis: | Tectona grandis (T. grandis) is a medicinal plant widely used in Cameroon to treat typhoid fever and several other diseases. Despite its heavy use for medical purposes, no study has yet been conducted to assess its potentially toxic effects. This study aimed at evaluating the acute and subchronic toxicological profile of Tectona grandis leaf extract in rats. The acute toxicity study revealed neither behavioral disturbances nor death in rats. The lethal dose (DL50) of this extract is greater than 5000 mg/kg body weight. The subchronic toxicity study showed no significant change in weight gain in rats at test doses throughout the treatment period. However, there was a significant decrease in alanine transaminase activity and serum protein levels at all doses. Alkaline phosphatase activity decreased at doses of 30, 90, and 270 mg/kg and increased at the dose of 810 mg/kg body weight. Serum and urinary urea levels increased simultaneously at doses of 270 and 810 mg/kg body weight. Repeated administration of the extract also increased total cholesterol, high-density lipoprotein levels in both sexes were compared to respective controls, and the ratio of high- to low-density lipoprotein was found to be greater than 1 in all animals. However, at the dose of 810 mg/kg, necrosis was observed on the kidney sections and vascular congestion on the liver sections of animals. Aqueous extract of T. grandis did not lead to any adverse effects in rats after acute and subchronic treatment at 30 and 90 mg/kg doses. This extract can, therefore, be used for the formulation of typhoid fever phytomedicine at the therapeutic dose of 30 mg/kg, but before this, chronic and mutagenic toxicity evaluations must be carried out. |
| Databáze: | OpenAIRE |
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