Intraoperative perfusion-weighted imaging in non-enhanced glioma surgery
| Autor: | Jian-Dong Zuo, Wei Guan, Zhong-Jun Chen, Wenguang Liu, Jin-Long Zheng, Jinyu Zheng |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Adult
Male Adolescent Malignancy Neurosurgical Procedures Magnetic resonance angiography Young Adult chemistry.chemical_compound Monitoring Intraoperative Glioma medicine Humans medicine.diagnostic_test business.industry Histology Magnetic resonance imaging Middle Aged medicine.disease Vascular endothelial growth factor Surgery Computer-Assisted Cerebral blood flow chemistry Immunohistochemistry Female Surgery business Nuclear medicine Magnetic Resonance Angiography |
| Zdroj: | Minerva Chirurgica. 74 |
| ISSN: | 1827-1626 0026-4733 |
| DOI: | 10.23736/s0026-4733.17.07453-3 |
| Popis: | BACKGROUND The objective of the present study was to observe and analyze the significance of perfusion-weighted imaging for guiding the operation implementation for non-enhanced glioma, and analyze the estimation of the histopathological grade of the non-enhanced glioma and the accuracy of the degree of malignancy degree before surgery. METHODS Fifty-six patients diagnosed with non-enhanced glioma through conventional magnetic resonance scanning were selected. Before surgery, conventional magnetic resonance scanning and perfusion-weighted imaging were performed on all patients. The property classification was performed with the perfusion-weighted imaging parameters: cerebral blood volume (CBV) and cerebral blood flow (CBF) before surgery. RESULTS Surgery was performed on the 56 patients. Tumors were excised and processed for histopathological classification and semi-quantitative immunohistochemical analysis of vascular endothelial growth factor (VEGF) levels. Histology was compared after surgery and the classification accuracy rate was analyzed before surgery. Additionally, conventional magnetic resonance scanning and perfusion-weighted imaging were performed on 15 patients during surgery. We compared and analyzed the reference value of perfusion-weighted imaging before and during surgery. Residual diseased tissues were excised; histopathological examination was performed, and semi-quantitative immunohistochemical analysis of VEGF was performed. Regarding maximal magnetic resonance perfusion-weighted imaging measured before surgery, the CBV, CBF, and expression level of VEGF were positively correlated with the pathological grade of tumors. If the CBV and CBF values of the non-enhanced glioma were higher, the grade of malignancy was higher (P |
| Databáze: | OpenAIRE |
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