Diverging prefrontal cortex fiber connection routes to the subthalamic nucleus and the mesencephalic ventral tegmentum investigated with long range (normative) and short range (ex-vivo high resolution) 7T DTI
| Autor: | Dominik von Elverfeldt, Marco Reisert, Peter C. Reinacher, Bastian Sajonz, Shi Jia Teo, Volker A. Coenen, Máté D. Döbrössy, Johanna Wessolleck, Björn Spittau, Annette Thierauf-Emberger, Thomas E. Schlaepfer, Jochen Leupold |
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| Přispěvatelé: | Publica |
| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
Histology Deep brain stimulation Neurology Tegmentum Mesencephali Deep Brain Stimulation medicine.medical_treatment Prefrontal Cortex High resolution deep brain stimulation (DRS) Subthalamic Nucleus Tegmentum medicine Major depression Prefrontal cortex Medial forebrain bundle Superolateral medial forebrain bundle General Neuroscience Hyperdirect pathways Medial Forebrain Bundle dMRI Subthalamic nucleus Obsessive compulsive disorder Original Article Anatomy Psychology Anterior limb of internal capsule Neuroscience Tractography |
| Zdroj: | Brain Structure & Function |
| ISSN: | 1863-2661 1863-2653 |
| Popis: | Uncertainties concerning anatomy and function of cortico-subcortical projections have arisen during the recent years. A clear distinction between cortico-subthalamic (hyperdirect) and cortico-tegmental projections (superolateral medial forebrain bundle, slMFB) so far is elusive. Deep Brain Stimulation (DBS) of the slMFB (for major depression, MD and obsessive compulsive disorders, OCD) has on the one hand been interpreted as actually involving limbic (prefrontal) hyperdirect pathways. On the other hand slMFB’s stimulation region in the mesencephalic ventral tegmentum is said to impact on other structures too, going beyond the antidepressant (or anti OCD) efficacy of sole modulation of the cortico-tegmental reward-associated pathways. We have here used a normative diffusion MRT template (HCP, n = 80) for long-range tractography and augmented this dataset with ex-vivo high resolution data (n = 1) in a stochastic brain space. We compared this data with histological information and used the high resolution ex-vivo data set to scrutinize the mesencephalic tegmentum for small fiber pathways present. Our work resolves an existing ambiguity between slMFB and prefrontal hyperdirect pathways which—for the first time—are described as co-existent. DBS of the slMFB does not appear to modulate prefrontal hyperdirect cortico-subthalamic but rather cortico-tegmental projections. Smaller fiber structures in the target region—as far as they can be discerned—appear not to be involved in slMFB DBS. Our work enfeebles previous anatomical criticism and strengthens the position of the slMFB DBS target for its use in MD and OCD. |
| Databáze: | OpenAIRE |
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