Acute Blocking of Naloxone-Precipitated Opiate Withdrawal Symptoms by Methohexitone
| Autor: | N Loimer, Kurt Lenz, Rainer Schmid, Josef Grünberger, O Presslich |
|---|---|
| Rok vydání: | 1990 |
| Předmět: |
Adult
Male 03 medical and health sciences 0302 clinical medicine Double-Blind Method Naloxone medicine Humans 030212 general & internal medicine Bolus injection Neurologic Examination Narcotic antagonist business.industry Opioid-Related Disorders Opiate withdrawal Substance Withdrawal Syndrome 030227 psychiatry Psychiatry and Mental health Methohexital Anesthesia Opiate withdrawal symptoms Drug Therapy Combination Female Withdrawal syndrome business medicine.drug |
| Zdroj: | British Journal of Psychiatry. 157:748-752 |
| ISSN: | 1472-1465 0007-1250 |
| DOI: | 10.1192/bjp.157.5.748 |
| Popis: | In a double-blind placebo-controlled trial of 18 patients, methohexitone blocked objective signs of opiate withdrawal caused by a bolus injection of naloxone. Furthermore, in continuing the naloxone therapy for 48 hours, no withdrawal signs appeared. Levels of withdrawal distress returned to normal levels within six days. This approach can be regarded as an effective and well tolerated withdrawal therapy with low drop-out rates. |
| Databáze: | OpenAIRE |
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