Paraneoplastic pemphigus without antibodies to desmoglein 1 and
| Autor: | Nadarajah Vigneswaran, Kelsey Flood, Christopher M Stroud, Sylvia Hsu, Zelmira Lazarov |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty Pemphigoid integumentary system business.industry Pemphigus vulgaris paraneoplastic pemphigus stomatitis desmoglein desmoglein compensation theory Dermatology General Medicine Malignancy medicine.disease Desmoglein 03 medical and health sciences Pemphigus 030104 developmental biology 0302 clinical medicine Paraneoplastic pemphigus immune system diseases Desmoglein 1 030220 oncology & carcinogenesis medicine skin and connective tissue diseases business Stomatitis |
| Zdroj: | Flood, Kelsey; Stroud, Christopher; Lazarov, Zelmira; Vigneswara, Nadarajah; & Hsu, Sylvia. (2018). Paraneoplastic pemphigus without antibodies to desmoglein 1 and. Dermatology Online Journal, 24(2). Retrieved from: http://www.escholarship.org/uc/item/46z8v7jv |
| ISSN: | 1087-2108 |
| DOI: | 10.5070/d3242038110 |
| Popis: | Paraneoplastic pemphigus is a severe autoimmune blistering disease presenting in the setting of underlying malignancy. Paraneoplastic pemphigus is associated with diffuse painful stomatitis throughout the oral cavity with extension to the lips. The cutaneous findings are varied and have been described as lichenoid, pemphigoid, and targetoid lesions. Herein, we report a patient with paraneoplastic pemphigus whose routine testing led to a diagnosis of pemphigus vulgaris. However, further testing was pursued revealing an antibody profile consistent with paraneoplastic pemphigus. Subsequent neoplastic workup revealed an intra-abdominal mass. Our case represents a subtle, non-classic presentation of paraneoplastic pemphigus and suggests the importance of a comprehensive investigative work-up in atypical cases of pemphigus. |
| Databáze: | OpenAIRE |
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