Squamous cell carcinoma of base of tongue in a patient with Fanconi's anemia treated with radiation therapy: Case report and review of literature
| Autor: | Sarbani Ghosh Laskar, Vedang Murthy, Tanweer Shahid, Ashwini Budrukkar, Mandar S. Deshpande, Jai Prakash Agarwal, Babu Rao Vundinti, Tabish Hussain, Rita Mulherkar, Manju Sengar |
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| Rok vydání: | 2009 |
| Předmět: |
Adult
Male Oncology medicine.medical_specialty Anemia medicine.medical_treatment Leukocyte Count Fanconi anemia Internal medicine medicine Humans Basal cell carcinoma Aplastic anemia business.industry Head and neck cancer Cancer Radiotherapy Dosage medicine.disease Tongue Neoplasms Surgery Radiation therapy Fanconi Anemia Otorhinolaryngology Epidermoid carcinoma Carcinoma Squamous Cell business |
| Zdroj: | Head & Neck. 32:1422-1427 |
| ISSN: | 1043-3074 |
| Popis: | Background. Fanconi's anemia (FA) is a rare autosomal recessive genetic disorder characterized by congenital anomalies, progressive aplastic anemia, and a predisposition for malignancies. Solid tumors in the head and neck region, especially in the tongue, are rarely observed. Management of these patients is a challenge because of hematological complications and increased toxicities. Methods. We report a case of Fanconi's anemia in a 27-year-old man with carcinoma of the base of tongue (T2N0M0) who was treated with radical radiation therapy to a dose of 70 Gy/35 fractions/51 days. We have also done in vitro radiosensitivity tests. Results. The patient tolerated the radiation treatment well and completed it without any interruptions. In vitro studies did not show any increased radiosensitivity in this patient. Conclusion. Head and neck cancer in a patient with FA requires individualized treatment. The decision about opting for different modalities should be based on a balanced approach with respect to locoregional control and toxicities of the treatment. © 2009 Wiley Periodicals, Inc. Head Neck, 2010 |
| Databáze: | OpenAIRE |
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