Rapid ESI–MS method for examining the thermal decomposition of pharmaceuticals
| Autor: | W. Zhou, R.K. Gilpin |
|---|---|
| Rok vydání: | 2004 |
| Předmět: |
Spectrometry
Mass Electrospray Ionization Differential Thermal Analysis Chromatography Mefenamic acid Chemistry Electrospray ionization Thermal decomposition Pharmaceutical Science Mass spectrometry High-performance liquid chromatography Decomposition Triple quadrupole mass spectrometer Pharmaceutical Preparations Differential thermal analysis medicine Organic chemistry medicine.drug |
| Zdroj: | Journal of Pharmaceutical Sciences. 93:1545-1556 |
| ISSN: | 0022-3549 |
| DOI: | 10.1002/jps.20082 |
| Popis: | A Finnigan MAT TSQ 700 triple quadrupole mass spectrometer equipped with a Harvard 22 syringe pump has been used to investigate the thermal decomposition of three common pharmaceuticals, acetaminophen, indomethacin, and mefenamic acid. In addition, comparative measurements on these same drugs were carried out by HPLC after thermally degrading them at elevated temperatures in order to evaluate the usefulness of the ESI-MS as a rapid means of determining the relative stability and identifying thermal decomposition products. Similar results were obtained between the two techniques (i.e., the relative rates of decomposition were mefenamic acid > indomethacin > acetaminophen), with the advantage that the ESI-MS approach was much quicker to perform. |
| Databáze: | OpenAIRE |
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