PHAEOCHROMOCYTOMA AND HYPERTROPHIC CARDIOMYOPATHY: APPARENT SUPPRESSION OF SYMPTOMS AND NORADRENALINE SECRETION BY CALCIUM-CHANNEL BLOCKADE
| Autor: | BeverlyH. Lorell, DoloresM. Shoback, David Serfas |
|---|---|
| Rok vydání: | 1983 |
| Předmět: |
Adult
endocrine system medicine.medical_specialty Nifedipine endocrine system diseases Heart disease Urinary system medicine.medical_treatment Adrenal Gland Neoplasms Pheochromocytoma Norepinephrine (medication) Norepinephrine Double-Blind Method Internal medicine medicine Humans Clinical Trials as Topic Chemotherapy business.industry Hypertrophic cardiomyopathy General Medicine Cardiomyopathy Hypertrophic Calcium Channel Blockers medicine.disease Endocrinology Catecholamine Female business medicine.drug |
| Zdroj: | The Lancet. 322:711-713 |
| ISSN: | 0140-6736 |
| DOI: | 10.1016/s0140-6736(83)92250-x |
| Popis: | A 44-year-old woman with hypertrophic cardiomyopathy and a noradrenaline-secreting phaeochromocytoma is described. She experienced as great improvement in cardiovascular symptoms during double-blind treatment with the calcium-channel blocker nifedipine compared with the placebo period. Symptom relief on nifedipine therapy was associated with a pronounced decline in elevated urinary noradrenaline levels. This observation suggests that calcium-channel blockers interfere with the release of noradrenaline from phaeochromocytoma tissue and thus may be beneficial in patients with phaeochromocytoma. |
| Databáze: | OpenAIRE |
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