The anticataleptic effect of 7-OH-DPAT: are dopamine D 3 receptors involved?
| Autor: | Zofia Rogóż, Grazyna Skuza, Jerzy Maj |
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| Rok vydání: | 1999 |
| Předmět: |
Male
Fluphenazine medicine.medical_specialty Dextroamphetamine Pyrrolidines Quinpirole Reserpine Tetrahydronaphthalenes Dopamine Agents Hyperkinesis Naphthalenes Catalepsy Pharmacology Levodopa chemistry.chemical_compound Dopamine receptor D3 Internal medicine polycyclic compounds medicine Animals Rats Wistar Amphetamine Biological Psychiatry Brain Chemistry 7-OH-DPAT Receptors Dopamine D2 musculoskeletal neural and ocular physiology Receptors Dopamine D3 Nafadotride medicine.disease Rats Psychiatry and Mental health Endocrinology Neurology chemistry Dopamine Agonists Dopamine Antagonists Haloperidol Neurology (clinical) Locomotion Antipsychotic Agents medicine.drug |
| Zdroj: | Journal of Neural Transmission. 106:1063-1073 |
| ISSN: | 1435-1463 0300-9564 |
| DOI: | 10.1007/s007020050223 |
| Popis: | The paper examined the effect of 7-OH-DPAT (7-hydroxy-N,N-di-n-propyl-2-aminotetralin), a dopamine D3 receptors-prefering agonist, on the catalepsy evoked by reserpine, haloperidol and fluphenazine in rats (male Wistar), as well as the influence of nafadotride, a dopamine D3 receptors-prefering antagonist, on that effect. The obtained results show that 7-OH-DPAT, as well as L-DOPA, a drug of choice in the therapy of Parkinson's disease, used for comparison, antagonize the catalepsy induced by reserpine, haloperidol and fluphenazine. Nafadotride, used in a dose (0.2 mg/kg) which inhibits the 7-OH-DPAT-evoked locomotor hyperactivity but does not affect the hypermotility induced by amphetamine and quinpirole, antagonizes the anticataleptic effect of 7-OH-DPAT or L-DOPA. It is therefore assumed that dopamine D3 receptors are involved in the anticataleptic effect of both 7-OH-DPAT and L-DOPA. |
| Databáze: | OpenAIRE |
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