Adverse effects of perinatal illness severity on neurodevelopment are partially mediated by early brain abnormalities in infants born very preterm
| Autor: | J. Tan, Omid Fathi, M. Klebanoff, Julia E. Kline, J. W. Logan, Nehal A. Parikh, Lili He, M. Skalak |
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| Rok vydání: | 2020 |
| Předmět: |
Mediation (statistics)
Pediatrics medicine.medical_specialty Gestational Age Article 03 medical and health sciences 0302 clinical medicine 030225 pediatrics medicine Humans Illness severity 030212 general & internal medicine Cortical surface Adverse effect early prediction cortical brain development neurodevelopment medicine.diagnostic_test business.industry Infant Newborn Brain Infant Obstetrics and Gynecology Magnetic resonance imaging brain injury Magnetic Resonance Imaging Very preterm Neurodevelopmental Disorders Child Preschool Infant Extremely Premature Pediatrics Perinatology and Child Health Gestation business Clinical risk factor illness-severity |
| Zdroj: | Journal of perinatology : official journal of the California Perinatal Association |
| ISSN: | 1476-5543 0743-8346 |
| DOI: | 10.1038/s41372-020-00854-1 |
| Popis: | Background We sought to determine the mediating effects of magnetic resonance imaging (MRI) biomarkers at term gestation on the relationship between perinatal illness severity and neurodevelopment. Methods The Clinical Risk Index for Babies-second edition (CRIB-II) was correlated with indices of brain maturation or injury and neurodevelopment at 2-year follow-up in infants born less than 32 weeks gestation. Using a counterfactual mediation analysis, associations between CRIB-II, MRI biomarkers, and neurodevelopment were confirmed, followed by an assessment of the mediating effects of MRI biomarkers on the relationship between CRIB-II and neurodevelopment. Results CRIB-II correlated significantly with neurodevelopment and MRI biomarkers of brain injury or cortical maturation. Two MRI biomarkers, cortical surface area and global injury score, were associated with neurodevelopmental scores at follow-up and included in mediation analyses. Conclusion Biomarkers of cortical maturation or brain injury at term-equivalent age mediated a substantial portion of the risks conveyed by perinatal illness severity on neurodevelopmental outcomes at 2 years corrected age. |
| Databáze: | OpenAIRE |
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