Postnatal development of metallophilic macrophages in the rat thymus
| Autor: | Natasa Milic, Milos D. Miljkovic, Milica Labudovic-Borovic, Ivana M. Lalić, Novica M. Milićević |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Male
Silver Staining Cell type Silver Rodent 040301 veterinary sciences Ontogeny Thymus Gland Rat Thymus 0403 veterinary science 03 medical and health sciences Cortex (anatomy) biology.animal Confidence Intervals medicine Animals Rats Wistar Postnatal day Medulla Analysis of Variance 0303 health sciences Thymic cortex General Veterinary biology Macrophages organic chemicals fungi 04 agricultural and veterinary sciences General Medicine Immunohistochemistry Rats Cell biology medicine.anatomical_structure 030301 anatomy & morphology Regression Analysis Female Monte Carlo Method |
| Zdroj: | Anatomia, Histologia, Embryologia. 49:433-439 |
| ISSN: | 1439-0264 0340-2096 |
| Popis: | Metallophilic macrophages (MMs) are a distinct cell type of the rodent thymus. Our previous research has focused on the morphological characteristics of MMs, as well as on the molecular mechanisms involved in the development and tissue positioning of these cells. However, the postnatal development of MMs has not been sufficiently studied. In the present study, we investigated the positioning of MMs in the rat thymus between postnatal day 0 (P0) and P30. On P0, MMs were evenly distributed all over the thymic tissue-that is, the cortex, cortico-medullary zone and medulla. From P0 to P15, the number of MMs in the thymic cortex significantly decreased, and after P15, this number did not change. Thus, the present study shows that on P15, MMs almost completely disappear from the thymic cortex and show their adult position in the cortico-medullary zone and in the medulla. |
| Databáze: | OpenAIRE |
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