Meiotic wave adds extra asymmetry to the development of female chicken gonads
| Autor: | Stafford Anjie, Ester Silveira Ramos, Nannan He, Maria Gomes Fernandes, A. Marijne Heeren, Ana de Melo Bernardo, Liesbeth van Iperen, Susana M. Chuva de Sousa Lopes, Toshiaki Noce |
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| Přispěvatelé: | Neurology, Obstetrics and gynaecology, CCA - Immuno-pathogenesis, CCA - Oncogenesis |
| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: |
Male
medicine.medical_specialty Embryonic Germ Cells SEXUAL-DIFFERENTIATION endocrine system Gonad MIGRATION Embryonic Development Ovary Biology DOUBLE-STRAND BREAKS Andrology EMBRYOS Cell Movement RIGHT OVARY Internal medicine PRIMORDIAL GERM-CELLS Testis RETINOIC ACID Genetics medicine Animals Meiotic Prophase I Research Articles Germ plasm Body Patterning EXPRESSION PATTERN Sex Characteristics Sexual differentiation urogenital system Biology and Life Sciences Embryo Cell Biology MOUSE GONADS MEIOSIS Meiosis medicine.anatomical_structure Endocrinology MEIOSE Female Germ line development Chickens Germ cell Developmental Biology Research Article |
| Zdroj: | Molecular reproduction and development, 82(10), 774-786. Wiley-Liss Inc. Molecular reproduction and development, 82(10), 774-86. Wiley-Liss Inc. Molecular Reproduction and Development, 82(10), 774-786 de Melo Bernardo, A, Heeren, A M, van Iperen, L, Fernandes, M G, He, N, Anjie, S, Noce, T, Ramos, E S & de Sousa Lopes, S M C 2015, ' Meiotic wave adds extra asymmetry to the development of female chicken gonads ', Molecular reproduction and development, vol. 82, no. 10, pp. 774-86 . https://doi.org/10.1002/mrd.22516 MOLECULAR REPRODUCTION AND DEVELOPMENT Molecular Reproduction and Development Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual) Universidade de São Paulo (USP) instacron:USP |
| ISSN: | 1040-452X |
| DOI: | 10.1002/mrd.22516 |
| Popis: | SUMMARY Development of female gonads in the chicken is asymmetric. This asymmetry affects gene expression, morphology, and germ cell development; consequently only the left ovary develops into a functional organ, whereas the right ovary remains vestigial. In males, on the other hand, both gonads develop into functional testes. Here, we revisited the development of asymmetric traits in female (and male) chicken gonads between Hamburger Hamilton stage 16 (HH16) and hatching. At HH16, primordial germ cells migrated preferentially to the left gonad, accumulating in the left coelomic hinge between the gut mesentery and developing gonad in both males and females. Using the meiotic markers SYCP3 and phosphorylated H2AFX, we identified a previously undescribed, pronounced asymmetryc meiotic progression in the germ cells located in the central, lateral, and extreme cortical regions of the left female gonad from HH38 until hatching. Moreover, we observed that—in contrast to the current view—medullary germ cells are not apoptotic, but remain arrested in pre‐leptotene until hatching. In addition to the systematic analysis of the asymmetric distribution of germ cells in female chicken gonads, we propose an updated model suggesting that the localization of germ cells—in the left or right gonad; in the cortex or medulla of the left gonad; and in the central part or the extremities of the left cortex—has direct consequences for their development and participation in adult reproduction. Mol. Reprod. Dev. 82: 774–786, 2015. © 2015 The Authors. Molecular Reproduction and Development published by Wiley Periodicals, Inc. |
| Databáze: | OpenAIRE |
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