Variability of Faecal Calprotectin in Inflammatory Bowel Disease Patients: An Observational Case-control Study

Autor:	Denis Franchimont, Patrick Stordeur, Fabian Brohet, Leila Amininejad, Julie Smet, Jade Ku, A Cremer, Jacques Devière, Marie Rose Bouvry, Claire Liefferinckx, André Van Gossum
Rok vydání:	2019
Předmět:	Adult Male medicine.medical_specialty Adolescent Intraclass correlation Coefficient of variation Gastroenterology Inflammatory bowel disease Specimen Handling 03 medical and health sciences Feces Young Adult 0302 clinical medicine inflammatory bowel disease Internal medicine medicine Gastro-entérologie Humans Rank correlation Aged Aged 80 and over business.industry variability Case-control study Faecal calprotectin General Medicine Middle Aged medicine.disease Inflammatory Bowel Diseases C-Reactive Protein 030220 oncology & carcinogenesis Case-Control Studies 030211 gastroenterology & hepatology Observational study Female business Leukocyte L1 Antigen Complex Biomarkers
Zdroj:	Journal of Crohn's and Colitis, 13 (11
ISSN:	1876-4479
Popis:	Background and Aims: Several factors have been reported to affect faecal calprotectin [FC] values, and significant variation in FC concentrations has been observed in inflammatory bowel disease [IBD] patients. We aimed to evaluate FC variability in IBD patients, and to assess the robustness of a single stool punch. Methods: This is a single-centre observational case-control study. Disease activity was assessed using endoscopic and clinical activity scores, as well as C-reactive protein levels. Stool samples were collected twice within a 1 to 6 days interval, and FC was measured on punches and homogenates by fluorometric enzyme immunocapture assay. Results: In all, 260 stool samples were collected from 120 patients. Intrastool variability was low, with an intraclass correlation coefficient for single measures between three punches from a single stool sample of 0.91, and median coefficient of variation [CV] of 17%. CV of two stool samples a few days apart [intra-individual variability] were significantly higher [p SCOPUS: ar.j info:eu-repo/semantics/published
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2fc80a3e3d92d00f2fb7173a41c3468f https://pubmed.ncbi.nlm.nih.gov/30944925 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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