Association of angiotensin-converting enzyme gene insertion/deletion polymorphism with decreased risk for basal cell carcinoma
| Autor: | Dimitris Avgoustidis, Sofia Spyridonidou, Nikolaos Goutas, Antonis Vylliotis, Eleftherios Vairaktaris, Nikolas Koronellos, Dimitris Vlachodimitropoulos, Christos Yapijakis |
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| Rok vydání: | 2012 |
| Předmět: |
Adult
Male medicine.medical_specialty Angiotensin receptor Heterozygote Skin Neoplasms Genotype Dermatology Peptidyl-Dipeptidase A Gene Frequency Risk Factors Internal medicine medicine Humans Basal cell carcinoma Allele Allele frequency Aged Aged 80 and over Polymorphism Genetic biology Homozygote Angiotensin-converting enzyme General Medicine Middle Aged medicine.disease Molecular biology Angiotensin II Genotype frequency Mutagenesis Insertional Endocrinology Carcinoma Basal Cell Case-Control Studies biology.protein Female Gene Deletion |
| Zdroj: | Archives of dermatological research. 305(4) |
| ISSN: | 1432-069X |
| Popis: | The incidence of basal cell carcinoma (BCC) is significantly reduced in individuals treated with inhibitors of angiotensin I-converting enzyme (ACE) that produces angiotensin II. The objective of this study was to investigate the possible association of a functional polymorphism in the ACE gene, which affects its transcription, with risk for BCC. In DNA samples of 92 patients with BCC and 103 healthy controls of Greek origin and comparable age and gender, we studied the ACE gene insertion/deletion (I/D) polymorphism. Fisher’s exact test was used for comparison of allele and genotype frequencies between the control and patients’ groups. The detected low expression I allele frequency in the group of BCC patients was significantly decreased compared to controls (15.8 vs. 31.1 %, respectively; P = 0.001). ID heterozygotes exhibited 3.06 times lower BCC risk, compared with DD homozygotes (P = 0.001; OR = 0.327, 95 % CI = 0.174–0.615). The protective role of I allele was particularly prominent in women (P = 0.007, OR = 0.299, 95 % CI = 0.125–0.716), while for men it exhibited a marginal level (P = 0.041). These findings indicate that the low expression ACE I allele carriers have a decreased risk for BCC. The protective effect of the ID genotype against BCC may be explained by a possible underlying mechanism involving the effect of produced angiotensin II levels on its receptors due to putatively different binding affinity. |
| Databáze: | OpenAIRE |
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