Palpable Ductal Carcinoma in Situ: Analysis of Radiological and Histological Features of a Large Series With 5-Year Follow-Up
| Autor: | Barbara Dall, Nisha Sharma, Sreekumar Sundara Rajan, Mark Lansdown, Abeer M Shaaban, Rashmi Verma |
|---|---|
| Rok vydání: | 2013 |
| Předmět: |
Cancer Research
medicine.medical_specialty Time Factors medicine.medical_treatment Sentinel lymph node Breast Neoplasms Tertiary Care Centers Breast cancer Biopsy medicine Humans Mammography Mastectomy Retrospective Studies medicine.diagnostic_test business.industry Retrospective cohort study Middle Aged Ductal carcinoma Prognosis medicine.disease Magnetic Resonance Imaging Occult Carcinoma Papillary Surgery Carcinoma Intraductal Noninfiltrating Oncology Female Ultrasonography Mammary Radiology Neoplasm Grading business Follow-Up Studies |
| Zdroj: | Clinical Breast Cancer. 13:486-491 |
| ISSN: | 1526-8209 |
| Popis: | Background Palpable pure DCIS is a rare entity that presents differently than screen-detected DCIS. The aim of this study was to evaluate the clinical, radiological, and pathological characteristics and management of pDCIS in a retrospective cohort of patients. Patients and Methods Patients diagnosed with pDCIS from January 1999 to December 2011 were identified from an electronic patient database and were included in this study. Results During this period, 669 cases of DCIS were diagnosed and 62 (9.3%) were pDCIS (mean age, 56.9 ± 15.1 years). The most common finding on ultrasound was mass in 43 patients (75%) and only 18 (33%) cases had calcification on mammography. The lesion was mammographically occult in 20 patients (37%). Ultrasound was more sensitive and delineated the pDCIS in 45 (80%) cases. Mean size of the pDCIS was 36.9 ± 30.4 mm and most were high grade (n = 42; 68%) and associated with comedo necrosis in 36 (59%). Most were oestrogen receptor (ER)-positive (n = 34; 62%), however 21 patients (38%) were ER-negative. Breast conservation was attempted in 30 patients (48%), however, because of involved margins further therapeutic surgery was needed in 10 patients (33%). Axillary surgery (sentinel lymph node biopsy or axillary nodal sampling) was performed in 34 patients (55%) and no lymph node metastasis was identified. During a medial follow-up of 60 months, 1 patient has developed a mastectomy scar recurrence and the rest remain disease-free. Conclusion Palpable DCIS is often occult on conventional radiological imaging and is generally associated with aggressive pathological features. Hence, careful individualized surgical planning through a multidisciplinary meeting is necessary for their management. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect